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Tanzania

General
Nowadays there are few areas of our planet where you can really experience the timeless wonder and separation from the hum drum we face in our daily lives. Visiting Africa is fascinating and provides a new perspective on another life, another
world. The vast, untamed and primitive landscape provides a perfect glimpse into a life which many miss as they go about their daily chores. A trip which includes the majestic splendour of Africa’s tallest peak, Mt Kilimanjaro, rates high on the list of the unofficial wonders of the world and one not to be missed if the opportunity arises.
Mt Kilimanjaro
This is the highest peak in all of Africa stretching 5895m above sea level. Actually a few years ago the height of the summit was reassessed and then dropped by approximately 10m with more accurate recording by global positioning satellite. However, this minimal change will not be noticed by most travellers! There are a number of routes up to the summit and obviously which route is taken will make a significant difference to both the difficulty of the trek and any potential medical difficulties. Travelling with sufficient and well experienced guides and porters, and being part of a well organised group, are probably the most important factors in protecting your health.
Travelling to Tanzania
Mt Kilimanjaro is situated just across the border from Kenya in the northern part of Tanzania. You can approach the region by a number of different routes including buses from Nairobi, travelling from Dar es Salaam or flights straight into Moshi. How you travel for your climb of Kilimanjaro makes quite a significant difference to some of the health issues which you may face along the way.
General Health Issues
Before you leave for your trip make sure you are in good enough general health. If you can’t even run up a flight of stairs without collapsing then a trip up Kilimanjaro might not be the best choice! If you are unsure then see your doctor and ask for his or her advice at an early stage - before you commit yourself to the trip.
Long-Haul Flights
Flying to either Nairobi or Dar es Salaam takes between 9 to 10 hours from most Western European centres. This is regarded as a ‘long-haul flight’ so make sure you realise the risks associated with blood clotting in the legs and drink plenty of still fluids (water is the best), walk around the plane and use compression stockings if you are at any particular risk. (DVT in travel - TMB)
Food & Water
In Africa, as in many other areas of the world, what you eat and what you drink are essential for your well being. Being part of a large group has its advantages but you also need to stick with food and water that suits you personally. Don’t take extra risks with what you eat or drink just because others seem to be okay. Have your own sensible rules and remember to care for your stomach! Dehydration is common while climbing in a hot climate just make sure the water you drink is pure. You will also lose salt through perspiration and this will need to be replaced by increasing the amount of salt you put on your food at meal times.
What shoes to wear
Remember this is a walking holiday so prepare well in advance. Obviously increase your walking at home before you leave but remember to also include some significant hill walks to test your shoes. Blisters and corns are regularly associated with poorly fitted and substandard boots so spend that extra to get a pair that suits you and supports both the arch of your foot and also your ankles. A slightly larger pair is essential to lessen the pressure on your feet. Good thick socks will help to absorb perspiration and cushion your feet against friction.
Clothes to bring
This is one of the most difficult areas to sort out. The weather and climate along your climb will vary from a beautiful Irish-like summer day, to a roasting hot, dehydrating scorcher to a chilly or freezing night when the sun retires after about 6 pm. You must pack light cotton clothing but warm enough for the chill of the evenings at altitude. A wide brimmed hat (and sun lotion) is essential to protect against sun burn.
Problems at Altitude
High altitude is defined as over approx 3500m and as you know Kilimanjaro is a whole lot higher. The affects of altitude can hit anybody but most commonly it is the fit younger traveller who experiences the most serious consequences and even death. The doctor who discusses your vaccines and malaria prophylaxis will talk through the issues relating to Altitude sickness and may prescribe a medication to lessen the risks in certain circumstances. But remember, this disease can kill so if you develop any possible symptoms (lightheadedness, headaches, altered gait etc) please report it to your guide immediately. (Altitude sickness - TMB)

Being part of a group
The main advantage of being part of a group is that each member can help look-out for others during the trip. Never get separated from your main party and always report it if you feel one of your group is not quite right medically. This may be the first signs of altitude sickness and you could quite literally save a life by your intervention.
Mosquitoes and Malaria
Mosquitoes do not tend to live above 2000m and so the risk of malaria while climbing Kilimanjaro does not occur. However, you have to get to that altitude first and so protection against mosquito bites and malaria prophylaxis will be essential for this trip. (Malaria protection - TMB)
Rabies Risks in Tanzania
Any warm blooded animal can transmit rabies and so it is extremely important that you avoid any contact with dogs, cats, monkeys, and other animals on the slopes of Mt Kilimanjaro such as hyrats and other beaver like creatures. Report any contact immediately to your group leader.
Vaccinations for visiting Tanzania
As you travel to Tanzania from Western Europe we normally recommend that you have a number of vaccinations to cover against a range of diseases. In certain patients it may also be worth considering further vaccination cover against conditions like Rabies and Hepatitis B. These should be talked through in detail with your vaccinating doctor.
After your visit
When you return home you must remember that certain diseases can present days, weeks or even months afterwards. If you develop any peculiar symptoms (fever, headache, diarrhoea, skin rash etc) please make contact so this can be urgently assessed.
In the vast majority of cases the traveller climbing Kilimanjaro will stay perfectly healthy and well providing they follow the main common sense rules. Have a great safe trip and enjoy some of the splendours that Africa has to provide.

Travel News Headlines WORLD NEWS

Date: Sat, 28 Sep 2019 20:04:29 +0200 (METDST)

Nairobi, Sept 28, 2019 (AFP) - A Canadian tourist died Saturday while parachuting from the top of Mount Kilimanjaro, Africa's highest peak and Tanzania's top tourist attraction.   Justin Kyllo, 51, was killed after his parachute failed to open, Tanzanian National Parks spokesman Pascal Shelutete said.   Kyllo had arrived in the country on September 20, he said.   Around 50,000 people climb the nearly 6,000-metre mountain, located near the northeastern frontier with Kenya, every year.
Date: Fri 20 Sep 2019
From: Daniel R. Lucey MD, MPH [edited]

ProMED-mail reports since 14 Sep [2019] of a Tanzanian woman who died in Dar es Salaam on 8 Sep [2019] and was declared negative for Ebola by Tanzanian officials raises the question of what did cause her death. Given her travel to Uganda in August [2019], perhaps bat-associated Sosuga virus could be tested for if stored specimens exist. Similar to this young woman from Tanzania, the initial patient from the USA working in Uganda in 2012 in whom Sosuga virus was discovered had [experienced] fever, headache, rash, and diarrhoea (EID 2014; 20: 211-216). This virus was found from fruit bats in Uganda in 3 locations approximately 130 km [about 81 mi] apart (J Wildl Dis 2015; 51:774-779). An IgM and IgG test was developed at the US Centers for Disease Control and Prevention, and antiviral compounds active against this virus were reported in 2018.

Daniel R. Lucey MD, MPH
Consultant, ProMED
=======================
[The fatal case of a young Tanzanian woman studying in Uganda who died after travelling back to Tanzania for her field studies, as reported in ProMED-mail post http://promedmail.org/post/20190914.6674377, continues to elude an aetiological diagnosis. The initial concern for Ebola infection has since effectively been ruled out (see http://promedmail.org/post/20190914.6674377), but outside observers have called for greater transparency and information sharing given widespread rumours surrounding this case and its potential public health implications for neighbouring countries as well as Tanzania itself (see http://promedmail.org/post/20190918.6680252).

As discussed by ProMED Mod.LK, the Ebola-like symptoms manifested in this case can be caused by other viral haemorrhagic fevers and a variety of other pathogens (see http://promedmail.org/post/20190914.6674377). ProMED thanks Dr. Lucey for raising the intriguing possibility of Sosuga virus in his letter. We continue to seek any additional information about this case, as well as alternative etiologic diagnoses and how they could be tested for.

Citations and URLs for the articles referenced by Dr. Lucey are as follows:

Albarino CG et al.: Novel Paramyxovirus Associated with Severe Acute Febrile Disease, South Sudan and Uganda, 2012. Emerg Infect Dis. 2014; 20(2): 211-216. <https://dx.doi.org/10.3201/eid2002.131620>.

Amman BR et al.: A Recently Discovered Pathogenic Paramyxovirus, Sosuga Virus, is Present in _Rousettus aegyptiacus_ Fruit Bats at Multiple Locations in Uganda. J Wild Dis. 2015; 51(3): 774-779. <https://www.jwildlifedis.org/doi/10.7589/2015-02-044>. - ProMED Mod.LXL]

[HealthMap/ProMED-mail map:
28 Jul 2019

As many as 13 have died while 6677 have been infected across Tanzania. In Dar es Salaam region alone, 6631 cases and 11 deaths have occurred.

HealthMap/ProMED-mail map of Tanzania:
Date: 20 Aug 2019
Source: Outbreak News Today [edited]

A suspected aflatoxicosis outbreak is being reported in Tanzania. The World Health Organization (WHO) was informed of the situation by the Ministry of Health in late June 2019. Since 1 Jun 2019, sporadic cases presented with symptoms and signs of abdominal distention, jaundice, vomiting, swelling of lower limbs, with a few cases of fever and headache, from Dodoma and Manyara Regions in Tanzania. As of 11 Aug 2019, a total of 53 cases and 8 deaths have been reported from Chemba, Kondoa and Kiteto Districts. The situation is under investigation.

Aflatoxin is a potent toxin and a very serious health issue in many parts of the developing world. Major outbreaks have been seen in Africa, India, Malaysia and Taiwan over the years. This mycotoxin is a natural toxin produced as a secondary metabolite to certain strains of the fungus _Aspergillus_ spp, in particular _Aspergillus flavus_ and _Aspergillus parasiticus_.

Aflatoxins are contaminants of foods intended for people or animals as a result of fungal contamination. The commonest foods implicated are cereals like corn, wheat and rice, oilseeds like peanuts and sunflower, and spices. However, the toxin can affect a very wide range of food stuffs (see below).

Different factors contribute to aflatoxin contamination. In semi-arid climates, the effect of drought can increase the amount of _Aspergillus_ spp in the air causing pre-harvest contamination of certain crops. Crops grown and stored in more tropical environments where the temperature and humidity are high usually have a higher risk of both pre and post-harvest contamination. Of course, much of the problem lies with homegrown crops not harvested or stored properly.

Aflatoxin poisoning can be divided into acute and chronic disease depending on the amount of toxin ingested. When people (or animals) ingest aflatoxin contaminated foods, the liver is the main target for disease. There is a direct link between aflatoxin poisoning and liver cancer. Liver cancer or hepatocellular carcinoma is an important public health concern in many parts of the world due to aflatoxin. According to the CDC, acute aflatoxin poisoning results in liver failure and death in up to 40 per cent of cases in some regions.

Besides the obvious health risks, there is the massive economic loss occurring in parts of the world that can't afford it. Prevention and control of aflatoxin in developing countries is mainly focused on good agricultural practices. Because it is impossible to completely eliminate this danger, in the United States feeds and grains are laboratory tested for levels of aflatoxins, and food with unacceptable levels are removed from the market.

Foods most commonly affected by aflatoxins (from the USDA's Food Safety Research Information Office): [linked from:

- cereals (maize, corn, sorghum, pearl millet, rice, wheat)
- oilseeds (peanut, soybean, sunflower, cotton)
- spices (chilies, black pepper, coriander, turmeric, ginger)
- tree nuts (almonds, pistachio, walnuts, coconut)
- dried fruits (sultanas, figs)
- cocoa beans
- milk, eggs, and meat products*

* Milk, eggs, and meat products are occasionally contaminated due to the consumption of aflatoxin-contaminated feed by animals.
====================
["Aflatoxins are toxic metabolites produced by certain fungi in/on foods and feeds. They are probably the best known and most intensively researched mycotoxins in the world. Aflatoxins have been associated with various diseases, such as aflatoxicosis, in livestock, domestic animals and humans throughout the world. The occurrence of aflatoxins is influenced by certain environmental factors; hence the extent of contamination will vary with geographic location, agricultural and agronomic practices, and the susceptibility of commodities to fungal invasion during preharvest, storage, and/or processing periods. Aflatoxins have received greater attention than any other mycotoxins because of their demonstrated potent carcinogenic effect in susceptible laboratory animals and their acute toxicological effects in humans. As it is realized that absolute safety is never achieved, many countries have attempted to limit exposure to aflatoxins by imposing regulatory limits on commodities intended for use as food and feed.

"Fungal growth and aflatoxin contamination are the consequence of interactions among the fungus, the host and the environment. The appropriate combination of these factors determines the infestation and colonization of the substrate, and the type and amount of aflatoxin produced. However, a suitable substrate is required for fungal growth and subsequent toxin production, although the precise factor(s) that initiates toxin formation is not well understood. Water stress, high-temperature stress, and insect damage of the host plant are major determining factors in mold infestation and toxin production. Similarly, specific crop growth stages, poor fertility, high crop densities, and weed competition have been associated with increased mold growth and toxin production. Aflatoxin formation is also affected by associated growth of other molds or microbes. For example, preharvest aflatoxin contamination of peanuts and corn is favored by high temperatures, prolonged drought conditions, and high insect activity; while postharvest production of aflatoxins on corn and peanuts is favored by warm temperatures and high humidity.

"Humans are exposed to aflatoxins by consuming foods contaminated with products of fungal growth. Such exposure is difficult to avoid because fungal growth in foods is not easy to prevent. Even though heavily contaminated food supplies are not permitted in the marketplace in developed countries, concern still remains for the possible adverse effects resulting from long-term exposure to low levels of aflatoxins in the food supply.

"Evidence of acute aflatoxicosis in humans has been reported from many parts of the world, namely the 3rd World Countries, like Taiwan, Uganda, India, and many others. The syndrome is characterized by vomiting, abdominal pain, pulmonary edema, convulsions, coma, and death with cerebral edema and fatty involvement of the liver, kidneys, and heart.

"Conditions increasing the likelihood of acute aflatoxicosis in humans include limited availability of food, environmental conditions that favor fungal development in crops and commodities, and lack of regulatory systems for aflatoxin monitoring and control.

"Because aflatoxins, especially aflatoxin B1, are potent carcinogens in some animals, there is interest in the effects of long-term exposure to low levels of these important mycotoxins on humans. In 1988, the IARC placed aflatoxin B1 on the list of human carcinogens. This is supported by a number of epidemiological studies done in Asia and Africa that have demonstrated a positive association between dietary aflatoxins and Liver Cell Cancer (LCC). Additionally, the expression of aflatoxin-related diseases in humans may be influenced by factors such as age, sex, nutritional status, and/or concurrent exposure to other causative agents such as viral hepatitis (HBV) or parasite infestation.

"The economic impact of aflatoxins derives directly from crop and livestock losses as well as indirectly from the cost of regulatory programs designed to reduce risks to animal and human health. The Food and Agriculture Organization (FAO) estimates that 25% of the world's food crops are affected by mycotoxins, of which the most notorious are aflatoxins. Aflatoxin losses to livestock and poultry producers from aflatoxin-contaminated feeds include death and the more subtle effects of immune system suppression, reduced growth rates, and losses in feed efficiency. Other adverse economic effects of aflatoxins include lower yields for food and fiber crops.

"In addition, the ability of aflatoxins to cause cancer and related diseases in humans given their seemingly unavoidable occurrence in foods and feeds make the prevention and detoxification of these mycotoxins one of the most challenging toxicology issues of present time."  <http://poisonousplants.ansci.cornell.edu/toxicagents/aflatoxin/aflatoxin.html>.

Aflatoxins are a huge challenge in developing countries as they affect crops, animals and people and people and animals consuming the crops or drinking milk from affected animals. It should be noted that this is not the 1st time Tanzania has experienced this situation from aflatoxin. We hope the authorities are able to track down and remove the contaminated product and render appropriate medical care for the affected individuals. - ProMED Mod.TG]

[HealthMap/ProMED map available at:
Date: Thu 29 May 2019 Source: XinHuaNet [edited] <http://www.xinhuanet.com/english/2019-05/30/c_138100702.htm>
Cholera has killed one and left 32 others hospitalized in Tanzania's commercial capital, Dar es Salaam, Tanzanian health minister Ummy Mwalimu said on Wed 28 May 2019. "The outbreak of the disease has been caused by failure to abide by hygienic regulations," the minister said.
She directed all municipal councils in the commercial capital to enact by-laws that impose stern punishment to people who empty cesspool tanks in the open when it rains. Instructions have been given to municipal council authorities to mete out stern punishment to anybody disposing sewage in their compounds, Mwalimu said.
Dar es Salaam chief medical officer Yudas Ndungile said most cholera patients came from Mchikichini, in Kariakoo, and places hardly reached by sewage vehicles, and that efforts should be put in place to reach those areas. ========================
[With the start of the rainy season in this area of East Africa, the number of cases of cholera will rise. The mortality from cholera and most diarrheal illnesses is related to non-replacement of fluid and electrolytes from the diarrheal illness.
As stated by Lutwick and colleagues (Lutwick LI, Preis J, Choi P. Cholera. In: Chronic illness and disability: the pediatric gastrointestinal tract. Greydanus DE, Atay O, Merrick J, editors. New York: Nova Bioscience; 2018:113-127), oral rehydration therapy can be life-saving in outbreaks of cholera and other forms of diarrhea:
"As reviewed by Richard Guerrant et al. (1), it was in 1831 that cholera treatment could be accomplished by intravenous replacement, and, although this therapy could produce dramatic improvements, not until 1960 was it 1st recognized that there was no true destruction of the intestinal mucosa, and gastrointestinal rehydration therapy could be effective, and the therapy could dramatically reduce the intravenous needs for rehydration. Indeed, that this rehydration could be just as effective given orally as through an orogastric tube (for example, refs 2 and 3) made it possible for oral rehydration therapy (ORT) to be used in rural remote areas and truly impact the morbidity and mortality of cholera. Indeed, Guerrant et al. (1) highlight the use of oral glucose-salt packets in war-torn Bangladeshi refugees, which reduced the mortality rate from 30% to 3.6% (4) and quotes sources referring to ORT as "potentially the most important medical advance" of the 20th century. A variety of formulations of ORT exist, generally glucose or rice powder-based, which contain a variety of micronutrients, especially zinc (5).
"The assessment of the degree of volume loss in those with diarrhoea to approximate volume and fluid losses can be found in ref 6 below. Those with severe hypovolemia should be initially rehydrated intravenously with a fluid bolus of normal saline or Ringer's lactate solution of 20-30 mL/kg followed by 100 mL/kg in the 1st 4 hours and 100 mL/kg over the next 18 hours with regular reassessment. Those with lesser degrees of hypovolemia can be rehydrated orally with a glucose or rice-derived formula with up to 4 L [4.2 qt] in the 1st 4 hours, and those with no hypovolemia can be given ORT after each liquid stool with frequent re-evaluation."
More ...

World Travel News Headlines

Date: Sun 3 Nov 2019
Source: Nigeria Centre for Disease Control (NCDC) [edited]

Highlights
- In the reporting week 44 (28 Oct - 3 Nov 2019), 11 new confirmed** cases were reported from Ondo (6) and Edo (5) states with one new death from Edo state.
- From 1 Jan - 3 Nov 2019, a total of 4396 suspected* cases have been reported from 23 states. Of these, 754 were confirmed positive, 19 were probable, and 3623 were negative (not a case).
- Since the onset of the 2019 outbreak, there have been 158 deaths in confirmed cases. Case-fatality ratio in confirmed cases is 21%.
- A total of 23 states (Edo, Ondo, Bauchi, Nasarawa, Ebonyi, Plateau, Taraba, Adamawa, Gombe, Kaduna, Kwara, Benue, Rivers, Kogi, Enugu, Imo, Delta, Oyo, Kebbi, Cross River, Zamfara, Lagos, and Abia) have recorded at least one confirmed case across 86 local government areas [LGAs] - Figure 1.
- 93% of all confirmed cases are from Edo (38%), Ondo (31%), Ebonyi (7%), Bauchi (7%), Taraba (5%), and Plateau (5%) states - Figure 1.
- Predominant age group affected is 21-40 years (range: greater than one month to 98 years; median age: 34 years) - Figure 6.
- The male-to-female ratio for confirmed cases is 1:1 - Figure 6.
- In the reporting week 44, no new healthcare worker was affected. A total of 19 healthcare workers have been infected since the onset of the outbreak in 10 states: Edo (6), Ondo (4), Ebonyi (2), Enugu (1), Rivers (1), Bauchi (1), Benue (1), Delta (1), Plateau (1) and Kebbi (1) with 2 deaths in Enugu and Edo states.
- Nine patients are currently being managed at various treatment centres across the country: Irrua Specialist Teaching Hospital (ISTH) treatment Centre (7) and Federal Medical Centre, Owo (2).
- A total of 8400 contacts have been identified from 21 states. Of these, 356 (4.2%) are currently being followed up, 7967 (94.8%) have completed 21 days follow-up, while 12 (0.1%) were lost to follow-up. A total of 132 symptomatic contacts have been identified, of which 65 (49.2%) have tested positive.
- National Lassa fever multi-partner, multi-sectoral Technical Working Group (TWG) continues to coordinate response activities at all levels.

Figures [available at the source URL above]
-------------------------------------------
Figure 1 [map]. Randomised distribution of confirmed Lassa fever cases in Nigeria as at 3 Nov 2019.
Figure 2 [map]. LGAs with confirmed Lassa fever cases in Nigeria as at 3 Nov 2019.
Figure 3 [graph]. Epicurve of Lassa fever confirmed cases (754) in Nigeria - week 01-44, 2019.
Figure 4 [graph]. November 2019. Weekly trends of Lassa fever confirmed cases in Nigeria, 2016/week 01-2019/week 44.
Figure 5 [graph]. Confirmed Lassa fever cases in Nigeria with state-specific case-fatality rates (CFR) as at 3 Nov 2019.
Figure 6 [graph]. Age-sex distribution of confirmed Lassa fever cases in Nigeria as at 3 Nov 2019.

*Suspected case describes any individual presenting with one or more of the following: malaise, fever, headache, sore throat, cough, nausea, vomiting, diarrhoea, myalgia, chest pain, hearing loss, and either (a) history of contact with excreta or urine of rodents or (b) history of contact with a probably or confirmed Lassa fever case within a period of 21 days of onset of symptoms, or any person with inexplicable bleeding/hemorrhagia.
**Any suspected case with laboratory confirmation (positive IgM antibody, PCR, or virus isolation)
==================
[The 11 new confirmed and 4396 suspected cases indicate that Lassa fever (LF) virus transmission is continuing. Nigeria should be in the period of the year when fewer cases usually occur, as illustrated in the graph in Figure 3 (at the source URL above), but more cases are still occurring. There has been a peak in case numbers between weeks 1 and 11 (January-March) over the past 3 years and probably will be the case again next year (2020).

The number of confirmed deaths has increased by 2 to 158. Fortunately, there are no new healthcare workers infected during this reporting period, and the total number of infected healthcare workers remains at 19, a likely indication that effective barrier nursing and the use of personal protective equipment are being employed. This outbreak remains widespread so far in 2019, with confirmed cases occurring in 23 states, and the number of affected LGAs remains at 86. ProMED-mail readers may wish to see the maps and graphs (Figures 1-6) that are available at the source URL above.

Transmission of LF virus occurs when individuals are in contact with rodent reservoir host excreta or are within healthcare facilities. It would be interesting to know whether the prevalence of Lassa fever virus has been increasing in populations of rodent hosts in areas where human cases are occurring.

Images of the rodent reservoirs of Lassa fever virus:
_Mastomys natalensis_:
_Mastomys erythroleucus_ and _Hylomyscus pamfi_:

There is no mention in the plans above of public education for avoidance of contact with these rodents and their excreta. - ProMED Mod.TY]

[Maps of Nigeria:
Date: Thu 14 Nov 2019
From: Larry Lutwick <lutwick.larry@mayo.edu> [edited]

Over the past 5 days, our health care facility in northwest Wisconsin, USA, has seen 3 women hospitalized with _E coli_ O157 infection. All presented with significant abdominal pain without fever and watery diarrhoea which in 2 progressed to bloody diarrhoea. None of the 3 have manifested any evidence of haemolytic-uremic syndrome. Both of the women seen by the Infectious Diseases service stated that their diet contains a lot of salads.

We would appreciate any reports of upswings in the number of cases of this process in the upper Midwest USA or elsewhere.
--------------------------------------------
Larry Lutwick MD
Eau Claire, Wisconsin
=========================
[Although the classical source of enterohemorrhagic _E. coli_ infections is ground beef, fresh produce as in salad ingredients are also well represented as vehicles of transmission. ProMED would appreciate any further reports as the country health departments work on this as yet small outbreak. - ProMED Mod.LL]

[HealthMap/ProMED map available at:
Wisconsin, United States: <http://healthmap.org/promed/p/250>]
Date: Tue 12 Nov 2019
Source: Daily Times [edited]

[_Naegleria fowleri_] has claimed another life in Karachi on [Mon 11 Nov 2019]. This was the 16th death reported in the ongoing year [2019] because of the disease. According to details, a 28-year-old resident of New Karachi area was brought to a private clinic 4 days ago where he died of the disease during treatment.

According to the researchers, _Naegleria_ has a fatality rate of more than 98%. Infections can happen when contaminated water enters the body through the nose. It cannot be passed person-to-person.

The amoeba travels from the nasal membranes to the brain. Symptoms are initially very mild, including a headache, stiff neck, fever, and stomach pain. Death usually occurs 5 to 7 days after infection.

_N. fowleri_ is a microscopic amoeba, which is a single-celled living organism. It can cause a rare and devastating infection of the brain called primary amoebic meningoencephalitis (PAM). The amoeba is commonly found in warm freshwater such as lakes, rivers, ponds, and canals.

Once the amoeba enters the nose, it travels to the brain where it causes PAM (which destroys brain tissue) and is usually fatal. Infections usually occur when it is hot for prolonged periods of time, which results in higher water temperatures and lower water levels.
====================
[Even though the weather has cooled considerably in northern parts of the country, Sindh province, which includes Karachi, continues to experience hot and humid climate which is conducive to the proliferation of the Naegleria parasite.

A public awareness message from the Government of Sindh Health Department can be seen at

Optimum chlorination is the key measure to prevent _Naegleria fowleri_ infection. In the absence of chlorination of the supply water in the city, residents need to clean water tanks and chlorinate water in the tanks. - ProMED Mod.UBA]

[HealthMap/ProMED map available at:
Date: Tue 12 Nov 2019
Source: Outbreak News Today [edited]

Moncton is a city of some 85,000 people in south-eastern New Brunswick, Canada. In a CBC [Canadian Broadcasting Corporation) report today [12 Nov 2019], it is reported that a 3rd Creutzfeldt-Jakob disease (CJD) case this year [2019] -- all 3 cases had cataract surgery at the Moncton Hospital.  In April [2019], Moncton Hospital reported the identification 2 separate cases where a patient with probable Creutzfeldt-Jakob disease (CJD) had cataract surgery in the facility.

Dr Gordon Dow, division head of infectious diseases at the Moncton Hospital, said even he was shocked when another case of CJD was discovered.  "I think even though there's the overwhelming weight of evidence suggesting that we've had a cluster of sporadic cases, there is no need for public alarm," Dow said. "This is not an indication that there's been an outbreak of CJD."

Prion diseases are rare, fatal, degenerative brain disorders that are thought to occur worldwide in both humans and animals. They belong to the general category of brain diseases called proteinopathies, which also includes Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). Although there are several forms of human prion disease, the most common is Creutzfeldt-Jakob disease (CJD).  Since January 1998, Canada has reported 1037 definitive and probable CJD cases and New Brunswick has seen 31 cases during this period.
Date: Mon 11 Nov 2019
Source: Pan American Health Organization (PAHO)

Mexico has become the 1st country in the world to receive validation from the World Health Organization (WHO) for eliminating dog-transmitted rabies as a public health problem. "Eliminating [dog-transmitted] rabies doesn't happen by accident," said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. "It takes political resolve, careful planning, and meticulous execution. I congratulate the Government of Mexico on this wonderful achievement and hope many other countries will follow its example."

Rabies causes 60,000 deaths each year, mainly in Asia and Africa. In Latin America and the Caribbean, new cases of rabies were reduced by more than 95 percent in humans and 98 percent in dogs since 1983.

"By eliminating human rabies transmitted by dogs, Mexico is showing the world that ending infectious diseases for the next generation is possible and is the right way forward," said PAHO Director, Carissa F Etienne.

Mexico's achievement
--------------------
In order to achieve elimination, the country has implemented a national strategy for the control and elimination of rabies. This includes free, mass vaccination campaigns for dogs, that have taken place since the 1990's with more than 80 percent coverage; continuous and effective surveillance; public awareness-raising campaigns; timely diagnosis; and the availability of post-exposure prophylaxis in the country's public health services.

As a result, the country went from registering 60 cases of human rabies transmitted by dogs in 1990, to 3 cases in 1999, and zero cases in 2006. The last 2 cases occurred in 2 people from the State of Mexico, who were attacked in 2005 and presented symptoms in 2006.

The validation process
----------------------
WHO considers a country to be free of rabies after registering 2 years of zero transmission of rabies to humans. However, there was previously no process to verify the achievement of this goal, until this was developed by PAHO/WHO. Mexico became the 1st country in the world to begin this in December 2016.

The validation process was extensive and included the creation of a group of independent international experts established by PAHO/WHO. It also included the preparation, by Mexico, of an almost 300-page file containing all historical information about the situation of rabies in the country. PAHO and its specialized center in veterinary public health, PANAFTOSA, accompanied and supervised the implementation of the validation process throughout.

The group of experts carried out a mission to Mexico in September 2018 to review the file and verify the country complied with all WHO requirements. In September 2019, the group recommended the Director General of WHO and PAHO validate the elimination.

Moving forward
--------------
In order to sustain elimination, PAHO/WHO recommends continuing all rabies prevention, surveillance and control actions, particularly as rabies virus continues to circulate among wild animals such as bats.

PAHO collaborated with the countries of the Americas to eliminate rabies through technical cooperation, staff training, periodic meetings between those responsible for the issue in-country, and through the provision of recommendations on international standards. As of September 2019, there have been zero cases of rabies transmitted by dogs in humans in the Americas.

In addition to rabies, Mexico eliminated onchocerciasis in 2015 and trachoma in 2017, 3 of the more than 30 infectious diseases and related conditions that PAHO's new Communicable Disease Elimination Initiative in the Region of the Americas has set as a goal for elimination from the continent by 2030.
===================
[This is certainly an outstanding achievement and should be celebrated by all. It is also an example to other countries.  Of course, someone acquiring rabies from a bat would be outside of this situation. This WHO/PAHO validation specifically refers to rabies acquired from dog bites. This is a great milestone. Congratulations Mexico! - ProMED Mod.TG]

[HealthMap/ProMED-mail map of Mexico:
Date: Mon, 18 Nov 2019 08:37:15 +0100 (MET)

Jakarta, Nov 18, 2019 (AFP) - An endangered Sumatran Tiger has mauled to death an Indonesian farmer and seriously injured a domestic tourist, a conservation official said Monday.   The fatal attack happened Sunday at the farmer's coffee plantation on Sumatra island where the 57-year-old wrestled with the big cat before it killed him, according to Genman Hasibuan, head of the South Sumatra conservation agency.   "The farmer was attacked while he was cutting a tree at his plantation," he told AFP on Monday.   The mauling came a day after the same tiger attacked a group of Indonesian tourists who were camping at a local tea plantation in South Sumatra's Mount Dempo region.

One of the tourists was rushed to hospital for wounds to his back after the cat stormed into his tent, Hasibuan said.   The animal, which remains loose in the protected-forest area, is believed to be one of just 15 critically endangered tigers in South Sumatra, which has seen five tiger attacks this year, including two fatal incidents, Hasibuan said.

Human-animal conflicts are common in the vast Southeast Asian archipelago, especially in areas where the clearing of rainforest to make way for palm oil plantations is destroying animals' habitats and bringing them into closer contact with people.   In March last year, a man was killed by a tiger in Sumatra's Riau province while several months earlier a tiger also killed a plantation worker in the area.   Sumatran tigers are considered critically endangered by protection group the International Union for Conservation of Nature, with 400 to 500 remaining in the wild.
Date: Fri, 15 Nov 2019 17:12:24 +0100 (MET)

Karachi, Nov 15, 2019 (AFP) - Pakistan has become the first country in the world to introduce a new typhoid vaccine, officials said Friday, as the country grapples with an ongoing outbreak of a drug-resistant strain of the potentially fatal disease.   The vaccine, approved by the World Health Organization (WHO), will be used during a two-week immunisation campaign in southern Sindh province.

Sindh is where most of Pakistan's 10,000 cases of typhoid have been documented since 2017.    "The two-week campaign beginning from today would target over 10 million children of nine months to 15 years of age," Azra Pechuho, the health minister in Sindh province, said in Karachi on Friday.   The new vaccines have been provided by Gavi, the Vaccine Alliance, to the Pakistani government free of cost.

After the two-week campaign, it will be introduced into routine immunisations in Sindh, and in other areas of Pakistan in the coming years.   Pakistan spends a meagre amount of its national resources on public health and a majority of its population remains vulnerable to contagious diseases such as typhoid.   In 2017, 63 percent of the typhoid cases documented and 70 percent of the fatalities were children, according to a joint press release from the Pakistani government, WHO and Gavi.
Date: Sat, 16 Nov 2019 05:50:25 +0100 (MET)
By Abhaya SRIVASTAVA

New Delhi, Nov 16, 2019 (AFP) - A thick grey smog choked New Delhi for the fifth day Saturday, adding to a mounting pollution health crisis, but retired naval commander Anil Charan is one of the vast majority of the city's 20 million inhabitants who do not wear a mask.   Indian media is packed with warnings about the risk of premature death, lung cancer and particular danger to children from PM2.5 -- tiny particles that get into the bloodstream and vital organs -- carried in the smog.   But the smartly-dressed Charan was among shoppers in Delhi's upmarket Khan Market district browsing the luxury clothes and jewellery stores without a mask, seemingly oblivious to the risk.   Many are too poor to afford protection but others simply do not like the way a pollution mask looks.

Charan, wearing aviator sunglasses, said it did not fit his "rough and tough" image.   "I have been brought up in this kind of atmosphere, the smog and all, so I am kind of used to it. And being a naval officer I think if I wear a mask I will think I am a sissy," he said.   Doctors say face masks must be worn and air purifiers used at home and in offices.   There are a variety of masks to choose from. A basic cloth version can cost as little as 50 rupees (70 US cents) but the protection they offer is debatable.    More reputable types start from 2,500 rupees ($34) while some Khan Market stores charge more than 5,500 rupees ($75) for top of the range imported models.

- Bare-faced bravado -
The mask-look worried a lot of the Khan Market shoppers and diners however. Some said the danger had been overblown.   "I know I am risking my health but I am not very comfortable wearing them (masks)," said Ritancia Cardoz, who works for a private company.   "I don't find it appealing," she told AFP.   Lopa Diwan, on a visit to the capital from the provinces, said the Delhi air was "not as bad as it is being made out to be."   "So many people advised me not to go to Delhi because of the pollution but I don't think it's that bad. I don't see people dying," she said.

Pollution -- blamed on industrial and car emissions mixed with stubble fires on thousands of farms surrounding the city -- has been building up each winter for the past decade. The past five years have been particularly bad.   The toxic air cuts short the lives of one million people in India every year, according to government research published earlier this year.    Concentrations of the most harmful airborne pollutants in Delhi are regularly about 20 times the World Health Organisation safe limit. That rams home the city's reputation as the world's most polluted capital.   Some foreign companies and embassies now do not let families move to Delhi, or at least give strong warnings about the pollution.

The Delhi government has given out hundreds of thousands of masks to children and closed schools for four of the past five days. Construction is banned and cars can only go on the roads on alternate days.   But still only a tiny number of inhabitants follow medical advice when outside. Rickshaw drivers who earn about $7 a day on an average say they cannot afford masks.   Chand Babu, a car park attendant at Khan Market, said he could buy one of the cheaper masks but it was too much of a hassle to wear.   "I have to blow the whistle all the time so it's inconvenient."   Babu does worry, however, about his three children who also do not have masks. "They go outside to play. The problem is real, but what do we do, tell me?"
Date: Sun, 17 Nov 2019 14:28:44 +0100 (MET)
By Filippo MONTEFORTE with Charles ONIANS in Rome

Venice, Nov 17, 2019 (AFP) - Venice's St Mark's Square was closed on Sunday as the historic city suffered its  third major flooding in less than a week, while rain lashing the rest of Italy prompted warnings in Florence and Pisa.   Venice's latest "acqua alta", or high water, hit 150 centimetres (just under five feet) on Sunday, lower than Tuesday's 187 centimetres -- the highest level in half a century -- but still dangerous.   "The water has stopped rising," tweeted mayor Luigi Brugnaro, who has estimated damage so far from the invading salt water at over one billion euros (dollars).   "High of 150 centimetres... Venice is working to restart," Brugnaro said after the sea water swamped the already devastated city where authorities have declared a state of emergency.   To the south, Tuscany president Enrico Rossi tweeted a warning of a "flood wave" on the Arno and said boards were being installed on the swollen river's banks in Pisa "as a precautionary measure".

The Italian army tweeted photos of paratroopers helping to bolster river defences in Pisa, with authorities monitoring the same river in Florence after heavy rain made it rise dramatically overnight.   Arno flooding devastated Renaissance jewel Florence in 1966, killing around 100 people and destroying thousands of priceless works of art. Civil protection units in Florence advised citizens "not to stand near the Arno's riverbanks".   Firefighters tweeted footage of a hovercraft being deployed to rescue stranded citizens in southern Tuscany's Grossetano province.

- Brief respite -
The renewed threat from exceptionally high tides in Venice came after a brief respite on Saturday.   Emergency workers removed temporary walkways from St Mark's Square as the water started to rise on Sunday, with only police and soldiers visible at around midday.   The top tourist site had already been shut for several hours on Friday as strong storms and winds battered the region, leaving it submerged by sea surges.

Churches, shops and homes have also been inundated in the Renaissance city, a UNESCO World Heritage site.   A massive infrastructure project called MOSE has been under way since 2003 to protect the city, but the multi-billion euro project has been plagued by cost overruns, corruption scandals and delays.   "We weren't expecting the high waters to be so exceptionally high," said Guido Fulgenzi, who had planned to open his cafe on St Mark's square this week.   "We're paying the price" for the MOSE project not being completed, he said, sloshing around in his flooded kitchen and pointing to Tuesday's high water mark on the wall.   The crisis has prompted the government to release 20 million euros ($22 million) in funds to tackle the devastation.   Culture Minister Dario Franceschini has warned that the task of repairing the city, where more than 50 churches have suffered damage, will be huge.

- Hotel reservations cancelled -
Residents whose houses have been hit are eligible for up to 5,000 euros in immediate government aid, while restaurant and shop owners can receive up to 20,000 euros and apply for more later.   Most of the city's cash machines were no longer working, making life even more difficult for tourists and Venetians.   "We didn't expect there to be so much water, now we're soaked," said French tourist Magali Mariolou, visiting Venice for her wedding anniversary.   "We'll come back another year when it's a bit drier. The boots are heavy, they're full of water!"

Older residents who remember the infamous "acqua alta" of 1966, when the water rose to 1.94 metres, say they have not seen such frequent flooding before.   Hotels reported cancelled reservations, some as far ahead as December, following the widespread diffusion of images of Venice underwater.   Tuesday's high waters submerged around 80 percent of the city, officials said.   Many, including Venice's mayor, have blamed the disaster on global warming and warned that the country prone to natural disasters must wake up to the risks posed by ever more volatile seasons.   The Serenissima, as the floating city is called, is home to 50,000 residents but receives 36 million visitors each year.
Date: Mon, 18 Nov 2019 06:41:11 +0100 (MET)

Wellington, Nov 18, 2019 (AFP) - Samoa finalised plans for a compulsory measles vaccination programme Monday, after declaring a state of emergency as a deadly epidemic sweeps the Pacific nation.   At least six fatalities, including five children, have been linked to the outbreak of the virus, which has also hit other island states such as Tonga and Fiji.   Samoa is the worst affected with more than 700 cases reported from across all areas of the country, prompting the government on Friday to invoke emergency powers.

Declaring a state of emergency, the government said plans for compulsory measles, mumps and rubella (MMR) immunisations would be published on Monday.   "MMR vaccinations for members of the public who have not yet received a vaccination injection is now a mandatory legal requirement for all of Samoa," it said.   A national emergency operations centre to coordinate the measles response in the nation of 200,000 people was opened on Monday, with children aged six months to 19 years and non-pregnant females aged 20-35 given priority.

However, no information was immediately available on how the vaccinations would be administered or whether those who were not immunised would face sanctions.   Children are the most vulnerable to measles, which typically causes a rash and fever but can also lead to brain damage and death.   Samoa has closed all schools, kindergartens and the country's only university in a bid to halt the spread of the virus.   New Zealand, which is experiencing its own measles outbreak in the Auckland region, will this week send 30 nurses, 10 doctors and 3,000 MMR doses to Samoa.

University of Auckland immunologist Helen Petousis-Harris said even though measles was already widespread, the mass rollout of vaccinations could help limit the number of cases and reduce the death count.   She said it was also important to boost Samoa's low levels of immunisation and help prevent future outbreaks.   "In Samoa, the proportion of people who are immune to measles is very, very low, one of the lowest in the world," she told AFP.   "So if they aren't able to improve that, this is going to happen again."   The country's vaccination programme was briefly suspended last year when two babies died shortly after being given the MMR vaccine.   Subsequent investigations found the problem was not the widely used vaccine but the fact that nurses had prepared it incorrectly.

Neighbouring Tonga last week announced government primary schools and kindergartens would be closed until later this month as the number of measles cases in the kingdom approaches 200.   Fiji has reported four cases but says they are contained to a township west of the capital Suva.