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Tanzania

General
Nowadays there are few areas of our planet where you can really experience the timeless wonder and separation from the hum drum we face in our daily lives. Visiting Africa is fascinating and provides a new perspective on another life, another
world. The vast, untamed and primitive landscape provides a perfect glimpse into a life which many miss as they go about their daily chores. A trip which includes the majestic splendour of Africa’s tallest peak, Mt Kilimanjaro, rates high on the list of the unofficial wonders of the world and one not to be missed if the opportunity arises.
Mt Kilimanjaro
This is the highest peak in all of Africa stretching 5895m above sea level. Actually a few years ago the height of the summit was reassessed and then dropped by approximately 10m with more accurate recording by global positioning satellite. However, this minimal change will not be noticed by most travellers! There are a number of routes up to the summit and obviously which route is taken will make a significant difference to both the difficulty of the trek and any potential medical difficulties. Travelling with sufficient and well experienced guides and porters, and being part of a well organised group, are probably the most important factors in protecting your health.
Travelling to Tanzania
Mt Kilimanjaro is situated just across the border from Kenya in the northern part of Tanzania. You can approach the region by a number of different routes including buses from Nairobi, travelling from Dar es Salaam or flights straight into Moshi. How you travel for your climb of Kilimanjaro makes quite a significant difference to some of the health issues which you may face along the way.
General Health Issues
Before you leave for your trip make sure you are in good enough general health. If you can’t even run up a flight of stairs without collapsing then a trip up Kilimanjaro might not be the best choice! If you are unsure then see your doctor and ask for his or her advice at an early stage - before you commit yourself to the trip.
Long-Haul Flights
Flying to either Nairobi or Dar es Salaam takes between 9 to 10 hours from most Western European centres. This is regarded as a ‘long-haul flight’ so make sure you realise the risks associated with blood clotting in the legs and drink plenty of still fluids (water is the best), walk around the plane and use compression stockings if you are at any particular risk. (DVT in travel - TMB)
Food & Water
In Africa, as in many other areas of the world, what you eat and what you drink are essential for your well being. Being part of a large group has its advantages but you also need to stick with food and water that suits you personally. Don’t take extra risks with what you eat or drink just because others seem to be okay. Have your own sensible rules and remember to care for your stomach! Dehydration is common while climbing in a hot climate just make sure the water you drink is pure. You will also lose salt through perspiration and this will need to be replaced by increasing the amount of salt you put on your food at meal times.
What shoes to wear
Remember this is a walking holiday so prepare well in advance. Obviously increase your walking at home before you leave but remember to also include some significant hill walks to test your shoes. Blisters and corns are regularly associated with poorly fitted and substandard boots so spend that extra to get a pair that suits you and supports both the arch of your foot and also your ankles. A slightly larger pair is essential to lessen the pressure on your feet. Good thick socks will help to absorb perspiration and cushion your feet against friction.
Clothes to bring
This is one of the most difficult areas to sort out. The weather and climate along your climb will vary from a beautiful Irish-like summer day, to a roasting hot, dehydrating scorcher to a chilly or freezing night when the sun retires after about 6 pm. You must pack light cotton clothing but warm enough for the chill of the evenings at altitude. A wide brimmed hat (and sun lotion) is essential to protect against sun burn.
Problems at Altitude
High altitude is defined as over approx 3500m and as you know Kilimanjaro is a whole lot higher. The affects of altitude can hit anybody but most commonly it is the fit younger traveller who experiences the most serious consequences and even death. The doctor who discusses your vaccines and malaria prophylaxis will talk through the issues relating to Altitude sickness and may prescribe a medication to lessen the risks in certain circumstances. But remember, this disease can kill so if you develop any possible symptoms (lightheadedness, headaches, altered gait etc) please report it to your guide immediately. (Altitude sickness - TMB)

Being part of a group
The main advantage of being part of a group is that each member can help look-out for others during the trip. Never get separated from your main party and always report it if you feel one of your group is not quite right medically. This may be the first signs of altitude sickness and you could quite literally save a life by your intervention.
Mosquitoes and Malaria
Mosquitoes do not tend to live above 2000m and so the risk of malaria while climbing Kilimanjaro does not occur. However, you have to get to that altitude first and so protection against mosquito bites and malaria prophylaxis will be essential for this trip. (Malaria protection - TMB)
Rabies Risks in Tanzania
Any warm blooded animal can transmit rabies and so it is extremely important that you avoid any contact with dogs, cats, monkeys, and other animals on the slopes of Mt Kilimanjaro such as hyrats and other beaver like creatures. Report any contact immediately to your group leader.
Vaccinations for visiting Tanzania
As you travel to Tanzania from Western Europe we normally recommend that you have a number of vaccinations to cover against a range of diseases. In certain patients it may also be worth considering further vaccination cover against conditions like Rabies and Hepatitis B. These should be talked through in detail with your vaccinating doctor.
After your visit
When you return home you must remember that certain diseases can present days, weeks or even months afterwards. If you develop any peculiar symptoms (fever, headache, diarrhoea, skin rash etc) please make contact so this can be urgently assessed.
In the vast majority of cases the traveller climbing Kilimanjaro will stay perfectly healthy and well providing they follow the main common sense rules. Have a great safe trip and enjoy some of the splendours that Africa has to provide.

Travel News Headlines WORLD NEWS

Date: Fri 6 Dec 2019
From: Paola De Benedictis <pdebenedictis@izsvenezie.it> [edited]

A 44-year-old man was admitted to a public hospital (ICU Bisceglie, Barletta-Andria-Trani province, Apulia region, Italy) on 8 Oct 2019 with a suspected rabies infection. At the time of admission, he presented acute respiratory distress. Due to his deteriorating clinical conditions, he was transferred to the ICU of a tertiary hospital (ICU Policlinico, Bari, Italy), where he died of rabies on 19 Nov 2019, after a hospital stay of 42 days. Antemortem laboratory diagnostic tests for rabies performed at the National and FAO Reference Centre for Rabies, IZSVe (Padova, Italy) confirmed the initial suspicion based on the patient's clinical history.

The man had been bitten on his right hand by an aggressive dog on 8 Sep 2019 on the Island of Zanzibar (Tanzania). He immediately underwent post-exposure prophylaxis, which consisted of wound washing with an antiseptic solution (Betadine and hydrogen peroxide) and rabies vaccination in absence of rabies immunoglobulin administration. However, the patient was immunocompromised due to a corticosteroid therapy prescribed to treat an autoimmune disease and, unfortunately, such an important anamnesis went unnoticed until the onset of the symptoms.

Despite the internationally coordinated efforts to achieve a global goal of zero human dog-mediated rabies deaths by 2030, rabies still reaps human victims. In most cases, appropriate post-exposure prophylaxis [PEP] can safely prevent the infection in humans. However, shortages in rabies immunoglobulin (RIG) still represent the main constraint for human death prevention. Pre-exposure prophylaxis (PrEP) makes administration of RIG unnecessary after a bite. In this particular case, PrEP and antibody titration of the victim before his travel might have saved his life. Of note, recent WHO recommendations reshape the PrEP protocol from 3 to 2 shots administered within one week (0-7). Moreover, we believe that enhanced awareness and information should be envisaged at different levels, and disseminated by travel health advisors, travel agents, and resorts or through official public health guidelines,  similarly to those recommended by the United States Centers for Disease Control (CDC-ATL, <https://wwwnc.cdc.gov/travel/destinations/traveler/none/Tanzania>, paragraph "Keep away from animals" under "Stay Healthy and Safe").
--------------------------------
Lidia Dalfino, MD, Bari hospital
Sergio Carbonara, MD, Bisceglie hospital
Paola De Benedictis, DVM, PhD, FAO RC, IZSVe
===================
[Zanzibar island is a popular tourist destination in a semi-autonomous region of Tanzania, located off the eastern coast of Africa. Its government has undertaken, with the support of NGOs, great efforts to control and eradicate canine rabies since the earlier decade of the century. This was done mainly by annual rabies vaccinations, leading to a significant decline in the number of clinically confirmed canine rabies cases. In 2015, the Zanzibar government felt close to officially declaring the island free from canine rabies but this goal was eventually not achieved. In October 2017, the Global Alliance for Rabies Control (GARC) informed that The local authorities were "working hard towards ensuring a 70% vaccination coverage across the entire island within next 2 months" and that Zanzibar "is very close to being declared the 1st region in Africa to be free from rabies." (<https://rabiesalliance.org/news/towards-freedom-canine-mediated-rabies-zanzibar-island-wide-strategic-dog-vaccination>). This end, unfortunately, has not yet been reached, as tragically demonstrated by the case described above.

According to media reports, the victim, a businessman from the city of Andria in southern Italy, was visiting Kiwengwa beach, a resort area in the northeast of the island. "The family had arrived only a day earlier in Zanzibar and was on an excursion in the area when the animal attacked him. The animal was reportedly suffering from rabies and the wound was treated by local medics, which included it being disinfected at the local hospital."

According to the report above, for which the authors, Drs De Benedictis, Dalfino, and Carbonara are gratefully acknowledged, PEP was applied in Zanzibar but did not include rabies immunoglobulin. The victim continued with his holiday before returning to Italy. "He showed no signs of ill health for 2 weeks after returning, but then towards the end of September (2019), he started to feel unwell. Speaking to a friend before he died, he said the symptoms had included high blood pressure and spasms." The friend told local media: "The rabies [pre-exposure] vaccination was not something he had because it was only recommended, and was not listed as compulsory. An absurdity. [He] was very unlucky." (<https://ananova.news/tourist-bitten-by-rabid-stray-dog-in-zanzibar-dies>.)

The US CDC website provides pre-travel vaccination advice to "all travellers", "most travelers", and "some travellers". Rabies is one of the 5 vaccines which "some travelers" to Tanzania should be vaccinated with "after consulting their doctors." It is recommended for the following groups:
- Travellers involved in outdoor and other activities (such as camping, hiking, biking, adventure travel, and caving) that put them at risk for animal bites;
- people who will be working with or around animals (such as veterinarians, wildlife professionals, and researchers);
- people who are taking long trips or moving to Tanzania;
- children, because they tend to play with animals, might not report bites, and are more likely to have animal bites on their head and neck. (<https://wwwnc.cdc.gov/travel/destinations/traveler/none/tanzania#vaccines-and-medicines>).

WHO's advice concerning pre-travel vaccination, for all destinations, fall in broad line with CDC's, while adding the following:

"Pre-exposure vaccination is also recommended for individuals travelling to isolated areas, or to areas where immediate access to appropriate medical care is limited, or to countries where modern rabies vaccines are in short supply and locally available rabies vaccines might be unsafe and/or ineffective." (<https://www.who.int/ith/vaccines/rabies/en/>).

Should immunocompromised travelers apply PrEP?
The availability of RIG at destination may influence such a decision. The advice of one's GP and/or travel medicine expert deserves to be sought in a timely fashion.

A report of previous cases of inadequate antibody response to rabies vaccine in an immunocompromised patient and a literature search revealing 15 additional immunocompromised patients, of whom 7 did not exhibit the minimum acceptable level of antibodies after a complete postexposure prophylaxis regimen, are available in ref 1 below.

Reference
---------
1. Kopel E, Oren G, Sidi Y, David D. Inadequate antibody response to rabies vaccine in immunocompromised patient. Emerg Infect Dis. 2012; 18(9): 1493-5;

[HealthMap/ProMED-mail maps:
Kiwengwa Beach, Zanzibar North, Tanzania:
Date: Sat, 28 Sep 2019 20:04:29 +0200 (METDST)

Nairobi, Sept 28, 2019 (AFP) - A Canadian tourist died Saturday while parachuting from the top of Mount Kilimanjaro, Africa's highest peak and Tanzania's top tourist attraction.   Justin Kyllo, 51, was killed after his parachute failed to open, Tanzanian National Parks spokesman Pascal Shelutete said.   Kyllo had arrived in the country on September 20, he said.   Around 50,000 people climb the nearly 6,000-metre mountain, located near the northeastern frontier with Kenya, every year.
Date: Fri 20 Sep 2019
From: Daniel R. Lucey MD, MPH [edited]

ProMED-mail reports since 14 Sep [2019] of a Tanzanian woman who died in Dar es Salaam on 8 Sep [2019] and was declared negative for Ebola by Tanzanian officials raises the question of what did cause her death. Given her travel to Uganda in August [2019], perhaps bat-associated Sosuga virus could be tested for if stored specimens exist. Similar to this young woman from Tanzania, the initial patient from the USA working in Uganda in 2012 in whom Sosuga virus was discovered had [experienced] fever, headache, rash, and diarrhoea (EID 2014; 20: 211-216). This virus was found from fruit bats in Uganda in 3 locations approximately 130 km [about 81 mi] apart (J Wildl Dis 2015; 51:774-779). An IgM and IgG test was developed at the US Centers for Disease Control and Prevention, and antiviral compounds active against this virus were reported in 2018.

Daniel R. Lucey MD, MPH
Consultant, ProMED
=======================
[The fatal case of a young Tanzanian woman studying in Uganda who died after travelling back to Tanzania for her field studies, as reported in ProMED-mail post http://promedmail.org/post/20190914.6674377, continues to elude an aetiological diagnosis. The initial concern for Ebola infection has since effectively been ruled out (see http://promedmail.org/post/20190914.6674377), but outside observers have called for greater transparency and information sharing given widespread rumours surrounding this case and its potential public health implications for neighbouring countries as well as Tanzania itself (see http://promedmail.org/post/20190918.6680252).

As discussed by ProMED Mod.LK, the Ebola-like symptoms manifested in this case can be caused by other viral haemorrhagic fevers and a variety of other pathogens (see http://promedmail.org/post/20190914.6674377). ProMED thanks Dr. Lucey for raising the intriguing possibility of Sosuga virus in his letter. We continue to seek any additional information about this case, as well as alternative etiologic diagnoses and how they could be tested for.

Citations and URLs for the articles referenced by Dr. Lucey are as follows:

Albarino CG et al.: Novel Paramyxovirus Associated with Severe Acute Febrile Disease, South Sudan and Uganda, 2012. Emerg Infect Dis. 2014; 20(2): 211-216. <https://dx.doi.org/10.3201/eid2002.131620>.

Amman BR et al.: A Recently Discovered Pathogenic Paramyxovirus, Sosuga Virus, is Present in _Rousettus aegyptiacus_ Fruit Bats at Multiple Locations in Uganda. J Wild Dis. 2015; 51(3): 774-779. <https://www.jwildlifedis.org/doi/10.7589/2015-02-044>. - ProMED Mod.LXL]

[HealthMap/ProMED-mail map:
28 Jul 2019

As many as 13 have died while 6677 have been infected across Tanzania. In Dar es Salaam region alone, 6631 cases and 11 deaths have occurred.

HealthMap/ProMED-mail map of Tanzania:
Date: 20 Aug 2019
Source: Outbreak News Today [edited]

A suspected aflatoxicosis outbreak is being reported in Tanzania. The World Health Organization (WHO) was informed of the situation by the Ministry of Health in late June 2019. Since 1 Jun 2019, sporadic cases presented with symptoms and signs of abdominal distention, jaundice, vomiting, swelling of lower limbs, with a few cases of fever and headache, from Dodoma and Manyara Regions in Tanzania. As of 11 Aug 2019, a total of 53 cases and 8 deaths have been reported from Chemba, Kondoa and Kiteto Districts. The situation is under investigation.

Aflatoxin is a potent toxin and a very serious health issue in many parts of the developing world. Major outbreaks have been seen in Africa, India, Malaysia and Taiwan over the years. This mycotoxin is a natural toxin produced as a secondary metabolite to certain strains of the fungus _Aspergillus_ spp, in particular _Aspergillus flavus_ and _Aspergillus parasiticus_.

Aflatoxins are contaminants of foods intended for people or animals as a result of fungal contamination. The commonest foods implicated are cereals like corn, wheat and rice, oilseeds like peanuts and sunflower, and spices. However, the toxin can affect a very wide range of food stuffs (see below).

Different factors contribute to aflatoxin contamination. In semi-arid climates, the effect of drought can increase the amount of _Aspergillus_ spp in the air causing pre-harvest contamination of certain crops. Crops grown and stored in more tropical environments where the temperature and humidity are high usually have a higher risk of both pre and post-harvest contamination. Of course, much of the problem lies with homegrown crops not harvested or stored properly.

Aflatoxin poisoning can be divided into acute and chronic disease depending on the amount of toxin ingested. When people (or animals) ingest aflatoxin contaminated foods, the liver is the main target for disease. There is a direct link between aflatoxin poisoning and liver cancer. Liver cancer or hepatocellular carcinoma is an important public health concern in many parts of the world due to aflatoxin. According to the CDC, acute aflatoxin poisoning results in liver failure and death in up to 40 per cent of cases in some regions.

Besides the obvious health risks, there is the massive economic loss occurring in parts of the world that can't afford it. Prevention and control of aflatoxin in developing countries is mainly focused on good agricultural practices. Because it is impossible to completely eliminate this danger, in the United States feeds and grains are laboratory tested for levels of aflatoxins, and food with unacceptable levels are removed from the market.

Foods most commonly affected by aflatoxins (from the USDA's Food Safety Research Information Office): [linked from:

- cereals (maize, corn, sorghum, pearl millet, rice, wheat)
- oilseeds (peanut, soybean, sunflower, cotton)
- spices (chilies, black pepper, coriander, turmeric, ginger)
- tree nuts (almonds, pistachio, walnuts, coconut)
- dried fruits (sultanas, figs)
- cocoa beans
- milk, eggs, and meat products*

* Milk, eggs, and meat products are occasionally contaminated due to the consumption of aflatoxin-contaminated feed by animals.
====================
["Aflatoxins are toxic metabolites produced by certain fungi in/on foods and feeds. They are probably the best known and most intensively researched mycotoxins in the world. Aflatoxins have been associated with various diseases, such as aflatoxicosis, in livestock, domestic animals and humans throughout the world. The occurrence of aflatoxins is influenced by certain environmental factors; hence the extent of contamination will vary with geographic location, agricultural and agronomic practices, and the susceptibility of commodities to fungal invasion during preharvest, storage, and/or processing periods. Aflatoxins have received greater attention than any other mycotoxins because of their demonstrated potent carcinogenic effect in susceptible laboratory animals and their acute toxicological effects in humans. As it is realized that absolute safety is never achieved, many countries have attempted to limit exposure to aflatoxins by imposing regulatory limits on commodities intended for use as food and feed.

"Fungal growth and aflatoxin contamination are the consequence of interactions among the fungus, the host and the environment. The appropriate combination of these factors determines the infestation and colonization of the substrate, and the type and amount of aflatoxin produced. However, a suitable substrate is required for fungal growth and subsequent toxin production, although the precise factor(s) that initiates toxin formation is not well understood. Water stress, high-temperature stress, and insect damage of the host plant are major determining factors in mold infestation and toxin production. Similarly, specific crop growth stages, poor fertility, high crop densities, and weed competition have been associated with increased mold growth and toxin production. Aflatoxin formation is also affected by associated growth of other molds or microbes. For example, preharvest aflatoxin contamination of peanuts and corn is favored by high temperatures, prolonged drought conditions, and high insect activity; while postharvest production of aflatoxins on corn and peanuts is favored by warm temperatures and high humidity.

"Humans are exposed to aflatoxins by consuming foods contaminated with products of fungal growth. Such exposure is difficult to avoid because fungal growth in foods is not easy to prevent. Even though heavily contaminated food supplies are not permitted in the marketplace in developed countries, concern still remains for the possible adverse effects resulting from long-term exposure to low levels of aflatoxins in the food supply.

"Evidence of acute aflatoxicosis in humans has been reported from many parts of the world, namely the 3rd World Countries, like Taiwan, Uganda, India, and many others. The syndrome is characterized by vomiting, abdominal pain, pulmonary edema, convulsions, coma, and death with cerebral edema and fatty involvement of the liver, kidneys, and heart.

"Conditions increasing the likelihood of acute aflatoxicosis in humans include limited availability of food, environmental conditions that favor fungal development in crops and commodities, and lack of regulatory systems for aflatoxin monitoring and control.

"Because aflatoxins, especially aflatoxin B1, are potent carcinogens in some animals, there is interest in the effects of long-term exposure to low levels of these important mycotoxins on humans. In 1988, the IARC placed aflatoxin B1 on the list of human carcinogens. This is supported by a number of epidemiological studies done in Asia and Africa that have demonstrated a positive association between dietary aflatoxins and Liver Cell Cancer (LCC). Additionally, the expression of aflatoxin-related diseases in humans may be influenced by factors such as age, sex, nutritional status, and/or concurrent exposure to other causative agents such as viral hepatitis (HBV) or parasite infestation.

"The economic impact of aflatoxins derives directly from crop and livestock losses as well as indirectly from the cost of regulatory programs designed to reduce risks to animal and human health. The Food and Agriculture Organization (FAO) estimates that 25% of the world's food crops are affected by mycotoxins, of which the most notorious are aflatoxins. Aflatoxin losses to livestock and poultry producers from aflatoxin-contaminated feeds include death and the more subtle effects of immune system suppression, reduced growth rates, and losses in feed efficiency. Other adverse economic effects of aflatoxins include lower yields for food and fiber crops.

"In addition, the ability of aflatoxins to cause cancer and related diseases in humans given their seemingly unavoidable occurrence in foods and feeds make the prevention and detoxification of these mycotoxins one of the most challenging toxicology issues of present time."  <http://poisonousplants.ansci.cornell.edu/toxicagents/aflatoxin/aflatoxin.html>.

Aflatoxins are a huge challenge in developing countries as they affect crops, animals and people and people and animals consuming the crops or drinking milk from affected animals. It should be noted that this is not the 1st time Tanzania has experienced this situation from aflatoxin. We hope the authorities are able to track down and remove the contaminated product and render appropriate medical care for the affected individuals. - ProMED Mod.TG]

[HealthMap/ProMED map available at:
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World Travel News Headlines

Date: Sat, 25 Jan 2020 11:49:16 +0100 (MET)
By Su Xinqi, Jerome TAYLOR

Hong Kong, Jan 25, 2020 (AFP) - Hong Kong on Saturday declared a new coronavirus outbreak as an "emergency" -- the city's highest warning tier -- as authorities ramped up measures to reduce the risk of further infections.   The announcement came as city leader Carrie Lam faced criticism in some quarters over her administration's response to the crisis.

Of the five people who have tested positive for the virus in Hong Kong so far, four arrived via a newly built high-speed train terminal which connects with the mainland.   That led to calls from some medical experts and politicians to limit, or even halt, arrivals from China, the epicentre of the outbreak with 41 people dead.

Lam held emergency meetings with health officials on Saturday morning after returning from Davos.   "Today I declare the lifting of the response level to emergency," she told reporters.   Schools and universities, which are currently on a Lunar New Year break, would remain closed until 17 February, Lam said.   All mainland arrivals to Hong Kong will now need to sign health declaration forms, she added, while public events including a new year gala and next month's marathon, would also be called off.    "We haven't seen serious and widespread infections (in Hong Kong), but we are taking this seriously and we hope to be ahead of the epidemic," Lam said.

- Tragic past -
Hong Kong has a recent experience of deadly viral outbreaks.    Nearly 300 people were killed by SARS in 2003, a tragedy that left a profound psychological impact on one of the most densely populated places on earth.   The city's ability to combat the crisis was hampered by moves in mainland China to cover up and play down the outbreak, leaving a lasting legacy of distrust among many Hong Kongers.   Animosity towards the mainland has intensified in recent years as Beijing tightens political control over the semi-autonomous territory.

The outbreak also comes at a sensitive time for Lam, who currently boasts record low approval ratings after seven months of pro-democracy protests.   "We must stand united so that we can prevent and control the disease," she said, in a nod to the political unrest.   The often violent protests have battered Hong Kong's reputation for stability and helped tip it into recession, with the recent virus outbreak compounding the city's economic woes.

Hospitals are already struggling with the winter flu season, but officials are isolating anyone with a history of travel to central China and those exhibiting respiratory tract infections that look similar to the virus.   So far some 300 people have been tested and monitored for the virus. Quarantine centres have been set up in remote holiday parks for anyone found to have come into close contact with people who tested positive.   On Saturday, officials announced a newly built but still-empty public housing block would be used for medical staff on the frontline who did not want to risk returning to their families.
Date: Sat, 25 Jan 2020 06:46:59 +0100 (MET)
By Mahmut Bozarslan and Fulya Ozerkan in Istanbu

Elazig, Turkey, Jan 25, 2020 (AFP) - A powerful earthquake has killed at least 20 people and injured more than 1,000 in eastern Turkey, as rescue teams searched through the rubble of collapsed buildings for survivors on Saturday.    At least 30 people were missing following the magnitude 6.8 quake on Friday night, which had its epicentre in the small lakeside town of Sivrice in the eastern province of Elazig.   "It was very scary, furniture fell on top of us. We rushed outside," 47-year-old Melahat Can, who lives in the provincial capital of Elazig, told AFP.   President Recep Tayyip Erdogan said all steps were being taken to aid people affected by the quake, which caused widespread fear.   "We stand by our people," Erdogan said on Twitter.

The Turkish government's disaster and emergency management agency (AFAD) said the quake hit Sivrice at around 8.55 pm (1755 GMT). Turkey lies on major faultlines and is prone to frequent earthquakes.    Turkish television showed images of people rushing outside in panic, as well as a fire on the roof of a building.   Interior, environment and health ministers, who were in the quake zone, said the casulties were in Elazig province and in the neighbouring province of Malatya, which lies to the southwest.

At least 20 people died and 1,015 others were wounded, according to AFAD.   "There is nobody trapped under the rubble in Malatya but in Elazig search and rescue efforts are currently under way to find 30 citizens," Interior Minister Suleyman Soylu said on Friday.   Rescue teams were searching for survivors trapped in a five-storey collapsed building in a village some 30 kilometres from Elazig, according to AFP journalists at the scene. One person was pulled alive from the rubble.   Emergency staff and people waiting at the scene lit fires in the streets to stay warm in freezing temperatures.   Sports centres, schools and guest houses had been opened to accommodate quake victims in Malatya.

- 'Everybody is in the street' -
Sivrice -- a town with a population of about 4,000 people -- is situated south of Elazig city on the shores of Hazar lake -- one of the most popular tourist spots in the region and the source of the Tigris river.   The lake is home to a "Sunken City", with archaeological traces dating back 4,000 years in its waters.

The tremor was felt in several parts of eastern Turkey near the Iraqi and Syrian borders, the Turkish broadcaster NTV reported, adding that neighbouring cities had mobilised rescue teams for the quake area.   "Everybody is in the street, it was very powerful, very scary," said Zekeriya Gunes, 68, from Elazig city, after the quakes caused a building to collapse on her street.   "It lasted quite long, maybe 30 seconds," added Ferda, 39. "I panicked and was undecided whether to go out in this cold or remain inside."

The US Geological Survey assessed the magnitude as 6.7, slightly lower than AFAD, adding that it struck near the East Anatolian Fault in an area that has suffered no documented large ruptures since an earthquake in 1875.   "My wholehearted sympathy to President @RTErdogan and the Turkish people following the devastating earthquake that has hit Turkey. Our search and rescue teams stand ready to assist," Greek Prime Minister Kyriakos Mitsotakis wrote on Twitter.   In Athens, the Greek premier's office said later that Mitsotakis had spoken by phone to Erdogan.   "The Turkish president... said Turkish teams had the situation under control for now and that it would be re-evaluated in the morning," his office added.

In 1999, a devastating 7.4 magnitude earthquake hit Izmit in western Turkey, leaving more than 17,000 people dead including about 1,000 in the country's largest city Istanbul.    In September last year, a 5.7-magnitude earthquake shook Istanbul, causing residents to flee buildings in the economic capital.   Experts have long warned a large quake could devastate the city of 15 million people, which has allowed widespread building without safety precautions.
Date: Fri, 24 Jan 2020 17:43:54 +0100 (MET)
By Albert Kambale with Samir Tounsi in Kinshasa

Masisi, DR Congo, Jan 24, 2020 (AFP) - In eastern DR Congo, thousands have fled violence to camps in the remote mountain forests where they battle cholera, hunger and misery in a forgotten humanitarian disaster.   Eastern Democratic Republic of Congo has long struggled with violence from several militia groups, a legacy of the 1990s Congo wars that dragged in neighbouring Uganda and Rwanda.   The region is now also the epicentre of the latest Ebola epidemic, which has killed more than 2,200 people since August 2018.

Away from the Ebola headlines, tens of thousands of people are scattered in squalid camps across the mountains around Masisi, where they have fled, traumatised by violence, starving and with no chance to return home.   "I fled my village after clashes broke out," said Gentille, a 26-year-old Hutu Congolese. "We could no longer go to the fields. Many people died because clashes broke out in the middle of the village, very early one morning."

That fighting broke out in November and December involving one of the so-called Mai-Mai militia, the Nduma Defense of the Congo-Renove (NDC-R) and a coalition of other armed rivals, according to UN experts.   Now Gentille, a mother of five lives in a camp of 8,000 displaced people.  Along with the unsanitary conditions, a lack of clean water and food, since late last year, a cholera and measles outbreak has worsened life in the camps.    Several anti-cholera treatment units have been opened by Doctors without Borders (MSF), which reports 520 cases and two deaths.    "Three of my children got cholera. One died," says Gentille. "Here in the camp, we do not have enough toilets. More than 180 people use the same toilet. Since it is always busy, the children defecate outside and all around."

Around 685,000 displaced people survive in the mountainous areas, estimates MSF, a figure the aid group hopes will draw attention of the donors.   A year after coming to power, President Felix Tshisekedi has promised far-reaching reforms and a crackdown on corruption. But militia violence and ethnic clashes still undermine security of populations in the east.
Date: Fri, 24 Jan 2020 18:26:22 +0100 (MET)

Kathmandu, Jan 24, 2020 (AFP) - Health authorities in Nepal on Friday confirmed that a student who returned from Wuhan, China tested positive for the new coronavirus, becoming the first South Asian country to report the deadly disease.   The 32-year-old student arrived in Nepal on January 9, and entered the Sukraraj Tropical and Infectious Disease Hospital in Kathmandu four days later after running a fever and reporting trouble breathing, hospital spokesperson Anup Bastola told AFP.

The health ministry confirmed the case in a statement.   "The results of a sample, sent to Hong Kong, have returned positive," Bastola told AFP.    "He was discharged after recovery. We are monitoring the patient and he and his family members are healthy. So are all the health workers in the hospital," Bastola said.

Nepal's health ministry also said in a statement that surveillance has been increased at the airport, "and suspicious patients entering Nepal are being monitored with correct manpower and equipment".   At least 26 people have been killed by the previously unknown SARS-like coronavirus. Cases have been reported in half a dozen countries, including the United States.
Date: Fri, 24 Jan 2020 20:16:23 +0100 (MET)

Antananarivo, Jan 24, 2020 (AFP) - At least 26 people have died in Madagascar after almost a week of heavy rain in the north-west of the island, the government said on Friday.   The tropical Indian Ocean nation is in the midst of an intense six-month rainy season that often results in casualties and widespread damage.   Flooding in the districts of Mitsinjo and Maevatanana has claimed at least 26 lives since Sunday, and 15 more people are still missing and thousands have been displaced, the National Bureau of Disaster Risk Management (BNGRC) announced on Friday.   Strips of road were swept away by the rains and access to affected areas has been cut off.

The BNGRC warned that flooding in lowland and rice-growing areas also posed a risk of "food insecurity and malnutrition".   A disruption in the supply of basic goods could also lead to surge in prices, it added.   Prime Minister Christian Ntsay declared the situation a "national loss".   "The government is calling on national figures and international partners to help the Malagasy people with emergency aid, early recovery, rehabilitation and reconstruction," spokeswoman Lalatiana Andriatongarivo said in a statement.   The rainy season usually stretches from October to April in Madagascar, a former French colony off Africa's south-eastern coast.

Global warming has increased the risk and intensity of flooding, as the atmosphere holds more water and rainfall patterns are disrupted.    Built-up urban areas with poor drainage systems are especially vulnerable to heavy downpours, scientists say.   Nine people were killed in January 2019 after heavy rains caused a building to collapse in the capital Antananarivo.   During this period, the country is also often hit by cyclones and other tropical storms.   Cyclone Belna landed in the northwest last month, killing at least two people and displacing hundreds.
Date: Fri 24 Jan 2020
Source: Fernando Eid (@fernandoeidok) via Twitter [in Spanish, trans. ProMED Mod.TY, edited]

The 1st case of [a] hantavirus [infection] was confirmed in our country [this year in 2020]. The affected individual is an adolescent who contracted the disease in the tropical area of Cochabamba [department].  [Byline: Fernando Eid]
============================
[El Dia has a video clip available on the above Twitter URL with additional information (in Spanish, trans. ProMED Mod.TY):

The affected individual is a 15-year-old boy who was just released from the hospital ICU. He had a febrile disease. He had been in the forested area in tropical Cochabamba. He is believed to have acquired his infection from virus in faeces of the long-tailed rat. There have been10 cases of hantavirus infections in Cochabamba with one death [over what period of time? - ProMED Mod.TY]].
======================
[Unfortunately, the specific circumstances under which this youth or the previous 2019 cases acquired their infections is not mentioned. Presumably they were in contact with excreta from infected rodent hosts. Infected rodents shed the virus in faeces, urine, and saliva. Sporadic cases of hantavirus pulmonary syndrome occur in the Bolivian tropics, including Cochabamba department.

The specific hantavirus involved in these or previous cases in 2013 or those in 2012, in Bolivia, is not given. In the lowland Amazon basin of Bolivia, the hantaviruses that are likely to be in tropical Cochabamba department and might be involved in these hantavirus pulmonary syndrome cases are Laguna Negra viruses with its rodent hosts, _Calomys laucha_, the small vesper mouse (<https://www.flickr.com/photos/cdtimm/4367939127/in/photolist-otqNuS-EwTizo-7DYQ8i-278Fjfq-owyXyD-osEZQs>), and _C. callosus_, the large vesper mouse (<http://www.faunaparaguay.com/calomyscallosus.html>), as well as Rio Mamore virus with _C. laucha_ and _Oligoryzomys microtis_, the small-eared pygmy rice rat (<https://www.reservacostanera.com.ar/wp-content/uploads/2011/02/colilargo-menor-oligoryzomys-flavescens2-JGV-e1298896507790.jpg>). - ProMED Mod.TY]

[HealthMap/ProMED-mail map:
Cochabamba, Bolivia: <http://healthmap.org/promed/p/55162>]
Date: Fri 24 Jan 2020
Source: Eagle [edited]

The commissioner for health in Edo state, Dr. Patrick Okundia, on Friday [24 Jan 2020] in Benin said 76 out of 175 suspected cases of Lassa fever tested positive to the epidemic.

Okundia made this known during a Lassa fever committee meeting chaired by the state deputy governor, Philip Shaibu, and a representative of the World Health Organization.

He said: "A total of 76 suspected cases of Lassa fever were confirmed yesterday [Thu 23 Jan 2020] in the state, and they are currently on admission in the Irrua Specialist Teaching Hospital. We have not recorded any new death but have also reduced our case fatality rate to less than 10%. The number of cases in the ward now is 34, and we have discharged over 28 patients that have been fully treated and cured."

In his remarks, Shaibu called on all hospitals across the 18 local government areas [LGAs] of the state to refer any suspected cases to Irrua Specialist hospital and isolation centres.

He said: "Ministries of environment, agriculture, education, information, and other relevant ministries should also step up in the area of public awareness of the people. The 18 local government councils of the state should call for an emergency meeting, which will include private health practitioners for the purpose of early referral."

On her part, the state coordinator of the World Health Organisation, Faith Ireye, revealed that contact tracing in the state is the best in the country. Ireye called on the people to practice simple handwashing to avert contracting the disease.
=================
[Edo state has had many Lassa fever cases in recent years. The state is prepared to deal with treatment of Lassa fever patients in its Imua Specialist Teaching Hospital. Presumably, all the confirmed cases acquired their infections from the environment that has been contaminated by Lassa fever virus shed by rodent hosts, rather than in hospitals and health centres. Handwashing is always a good practice but will not prevent virus exposure from contamination of food materials by infected rodents. A public health education campaign at the village level is necessary to prevent infections.

Images of the rodent reservoirs of Lassa fever virus:
_Mastomys natalensis_:
_Mastomys erythroleucus_ and _Hylomyscus pamfi_:

The pygmy mouse (_Mus baoulei_) has recently been implicated as a reservoir species in West Africa but not in Nigeria.

There is no specific mention in the plans above of public education for avoidance of contact with these rodents and their excreta. - ProMED Mod.TY]

[Maps of Nigeria:
Date: Fri 24 Jan 2020
Source: Uganda Ministry of Health Tweets [edited]

[This series of tweets is drawn from a video interview that is also available at the above Twitter URL.]

The Ugandan Health Minister confirms an outbreak of yellow fever in Moyo District, West Nile region and Buliisa District in the Hoima region of Uganda.

Original public tweets
------------------------
Minister of Health, @JaneRuth_Aceng confirms the outbreak of Yellow Fever in Moyo District in West Nile region and Buliisa District in Hoima region in #Uganda.

@WHOUganda country representative, @tegegny speaks about the Yellow fever vaccine. "The Yellow Fever vaccine is one of those vaccines where you need to be vaccinated only once," he says.

@MinofHealthUG has also applied to @gavi and WHO for inclusion of the Yellow Fever vaccination into the routine immunisation schedule. Having faced 4 outbreaks, #Uganda now qualifies to introduce Yellow Fever vaccine as a long term measure to prevent Yellow Fever outbreaks.

@JaneRuth_Aceng: We anticipate that within the next 2 weeks, vaccines will be available and vaccination will commence in Moyo and Buliisa districts.

@JaneRuth_Aceng: @MinofHealthUG has requested for the Yellow Fever vaccines from the International Coordination Group that manages global stock piles of Yellow Fever and Meningitis vaccines.

@MinofHealthUG working with partners have dispatched Rapid Response Teams to Moyo and Buliisa Districts to support investigations, active search for cases, community mobilization and sensitization.

@JaneRuth_Aceng: At this time, there was little suspicion, however, his blood sample was withdrawn and sent to @UVRIug [Uganda Virus Research Institute] for testing and results showed positive for Yellow fever virus.

@JaneRuth_Aceng: In Buliisa, there are also 2 confirmed cases. A 37-year old male and his 38-year old wife. The husband was a cattle farmer trading in milk between Uganda and the Democratic Republic of Congo (DRC).

They presented with symptoms of:
- fever
- vomiting
- diarrhea
- fatigue
- headache
- abdominal and joint pain
- confusion
- unexplained bleeding.

@JaneRuth_Aceng: Upon arrival, they got ill and on [3 Jan 2020] were admitted at Logobo Health Center III in Moyo District. They were later referred to Moyo General Hospital.

@JaneRuth_Aceng: In Moyo District, there are 2 confirmed cases, both are males who were dealing in cutting and trading timber between Uganda and South Sudan. On [2 Jan 2020], the 2 cases travelled from South Sudan to Moyo.
==========================
[These 2 small (2 infected individuals in each locality) yellow fever (YF) outbreaks are not interconnected, having occurred at 2 sites at far distances from each other. It is reassuring to learn that the Ministry of Health will be investigating these 2 sites and initiating vaccination in these areas in 2 weeks. There is no indication of the proportion of the residents in these areas who have been vaccinated for YF previously.

Yellow fever is no stranger in Uganda, and outbreaks occur sporadically. The most recent previous outbreak reported by the Ugandan Ministry of Health was in May 2019 after laboratory-confirmed cases were reported from Koboko in the Northern region and Masaka in the Central region districts -- regions 600 km (375 mi) apart. These cases are spillover from endemic sylvan (forest) maintenance of the virus. Maintaining 80%-90% vaccination coverage in these areas is important to prevent initiation of urban transmission of the virus that can quickly get out of hand.

A map showing the location of Buliisa District in the center-west part of Uganda can be accessed at <https://en.wikipedia.org/wiki/Buliisa_District>, and another showing Moyo District in the far north of the country can be seen at <https://en.wikipedia.org/wiki/Moyo_District>. - ProMED Mod.TY]

[HealthMap/ProMED-mail map:
Date: Fri, 24 Jan 2020 12:26:57 +0100 (MET)

Beijing, Jan 24, 2020 (AFP) - China has quarantined cities and shut major tourist attractions from Disneyland to the Forbidden City and a section of the Great Wall as it scrambles to stop a deadly SARS-like virus from spreading further.   The drastic moves come as hundreds of millions of people criss-crossed the country in recent days to celebrate the Lunar New Year holiday, which officially started Friday and is typically a joyous time of gatherings and public celebration.   Here is a rundown of the measures taken so far in an unprecedented quarantine effort:

- Cities under lockdown -
Public transport has been stopped in 13 cities in central Hubei province, with train stations shut, events cancelled and theatres, libraries and karaoke bars closed in some locations.   The epicentre of the outbreak is provincial capital Wuhan, the biggest city on lockdown, where the government has halted all travel out of the Yangtze River metropolis of 11 million.   Wuhan residents have been told to stay home and authorities are limiting the number of taxis allowed on roads. There are few flights available to the city, deepening the isolation.   Similar quarantine measures are being taken in the other, smaller cities. These include strict controls on weddings and funerals, temperature screening of people as they arrive and the suspension of online taxi services.   More than 41 million people in total are affected by the city shutdowns.

- Festivities cancelled -
Wuhan and Beijing have cancelled public events that usually attract hundreds of thousands of people to temples during the New Year holiday.   Gao Fu, head of the Chinese Center for Disease Control and Prevention, has asked China's 1.4 billion citizens to forego New Year gatherings and confine themselves at home until all is clear.   To discourage nationwide travel, the government also said all tickets for rail, air, road, or water transport could be refunded.

- Attractions closed -
The historic Forbidden City, a sprawling imperial palace in Beijing that is one of the country's most revered cultural sites, will temporarily close from Saturday.   Other famous landmarks including a section of the Great Wall, the Ming Tombs and Yinshan Pagoda are also not open to visitors.   Shanghai Disneyland said it would shut for an indefinite period "to ensure the health and safety of our guests and cast".   Women's Olympics football qualifiers scheduled for February 3-9 in Wuhan have been moved to the eastern city of Nanjing.

- Temperature checks -
Staff in full body protective suits were seen checking the temperatures of people entering a subway station in Beijing on Friday.   The country has ordered sterilisation and ventilation at airports and bus stations, as well as inside planes and trains, while travellers are being screened for fever.   Health authorities are urging people to wash their hands regularly, avoid crowded places, get plenty of fresh air and wear a mask if they have a cough.   In Wuhan, city authorities have made it mandatory to wear a mask in public places.   In response to skyrocketing demand for masks -- starting to sell out at pharmacies and on some popular websites -- China's industry and information technology ministry said it would "spare no effort in increasing supply".

- A new hospital -
In Wuhan, authorities are rushing to build a new hospital in a staggering 10 days as a rising number of patients are infected by the new coronavirus.   The facility is expected to be in use by February 3 and will have a capacity of 1,000 beds spread over 25,000 square metres, according to state media.   Dozens of excavators and trucks were filmed working on the site by state broadcaster CCTV.   Its construction began after reports surfaced of bed shortages in hospitals designated as dealing with the outbreak, which has now infected 830 people across China.
Date: Fri, 24 Jan 2020 11:22:00 +0100 (MET)

Beijing, Jan 24, 2020 (AFP) - China announced Friday it will close a section of the Great Wall and other famous Beijing landmarks to control the spread of a deadly virus that has infected hundreds of people across the country.   A range of Lunar New Year festivities have been cancelled to try to contain the virus, and Beijing's Forbidden City and Shanghai's Disneyland have also been closed temporarily.

The Ming Tombs and Yinshan Pagoda will also be closed from Saturday, the authority that oversees the sites said, while the Bird's Nest stadium -- the site of the 2008 Olympic Games -- was shuttered from Friday.   The Great Wall attracts around 10 million tourists a year and is a popular destination for visitors during the New Year holiday.   The Juyongguan section will close, while the Great Wall temple fair was cancelled at the Simatai section of the famous landmark.

Tourists at the Gubei water town by the Simatai section will have their temperature tested, the authority said in a statement on the WeChat social media app.   The Bird's Nest will be closed until January 30 in order to "prevent and control" the spread of the virus, authorities said. An ice and snow show taking place on the pitch will be closed.   The measures in the capital are the latest to try and control the outbreak of the new coronavirus, after authorities rapidly expanded a mammoth
quarantine effort that affected 41 million people in central Hubei province.

The previously unknown virus has caused alarm because of its similarity to SARS (Severe Acute Respiratory Syndrome), which killed hundreds across mainland China and Hong Kong in 2002-2003.   Although there have only been 29 confirmed cases in Beijing, city authorities have cancelled large-scaled Lunar New Year events this week.   The city government said it would call off events including two popular temple fairs, which have attracted massive crowds of tourists in past years.   Beijing's Forbidden City -- which saw 19 million visitors last year -- is usually packed with tourists during the Lunar New Year festival, when hundreds of millions of people travel across China.