Date: Wed 29 May 2019 Source: Xinhua [edited] <http://www.xinhuanet.com/english/2019-05/29/c_138100250.htm>
A fresh positive polio case was detected in Afghanistan's eastern province of Kunar, bringing the number of confirmed cases of poliovirus to 8 since January this year [2019], a public health official said on Wednesday [29 May 2019]. "A new polio case has been reported from Watapur district of Kunar province which permanently paralyzed a 3-month-old boy," Wahidullah Mayar, spokesperson for the Ministry of Public Health, tweeted.
The latest case is the 1st case from the eastern Afghan region this year [2019], and the rest of 7 cases have been reported from southern provinces, he added. Poliovirus can be rapidly transferred, and the only way [to prevent the disease] is vaccination, according to the official.
The ongoing insurgency and conflicts have been hindering the efforts to stamp out the infectious disease in the mountainous country, as more than 1 million children from areas inaccessible to vaccination teams missed the latest vaccination drive.  [byline: Xuxin] ========================
[As this media report is based on a governmental announcement, I suspect this case will be in next week's global update, providing information on the date of onset of paralysis. It is noteworthy that this is the 1st case reported in Kunar province this year (2019). This represents the 8th case of WPV1-associated paralysis reported by Afghanistan with date of onset since 1 Jan 2019.
A map of Afghanistan showing provinces and districts can be found at <http://ontheworldmap.com/afghanistan/administrative-map-of-afghanistan-with-provinces-and-districts.jpg>.  Watapur district is located in the north central part of Kunar province. The southern and eastern districts of Kunar province border with Khyber Pakhtunkhwa and the tribal districts of Pakistan. The region is known for civil unrest. - ProMED Mod.MPP]
Date: Mon, 13 May 2019 18:12:22 +0200

Jalalabad, Afghanistan, May 13, 2019 (AFP) - At least three people were killed and another 20 wounded in a series of blasts in the eastern Afghan city of Jalalabad on Monday, an official said.   Nangarhar provincial spokesman Attaullah Khogyani said three blasts rocked the city centre, and had taken place near an armoured police vehicle.   "The nature of explosions is not clear, but it could be IEDs," Khogyani said, using the acronym for improvised explosive devices.   "So far we can confirm three people have been killed and 20 wounded."

No group immediately claimed responsibility for the attack, but the area around Jalalabad is home to fighters from both the Taliban and the Islamic State group's Afghan affiliate.   On March 6, at least 16 people were killed in a suicide attack on a construction company in Jalalabad, which is near the Pakistan border.   Violence in Afghanistan has continued apace even during the holy month of Ramadan, and despite government calls for a ceasefire.
Date: Sat, 11 May 2019 14:59:03 +0200

Ghazni, Afghanistan, May 11, 2019 (AFP) - A landmine explosion killed seven children and wounded two others in southern Afghanistan on Saturday, officials said, as war ordnance again claimed civilian lives.   The blast occurred in Ghazni province, south of the capital Kabul, when the children stepped on a landmine while playing near a main road, provincial spokesman Aref Noori told AFP.   "The mine was planted by the Taliban on a main road to inflict casualties on security forces," he said.   The Taliban did not immediately respond to a request for comment.   The insurgents often use roadside bombs and landmines to target Afghan security forces, but the lethal weapons also inflict casualties on civilians.   Amanullah Kamrani, a member of Ghazni provincial council, said the children were aged between seven and nine and at least four of them belonged to one family. 

Years of conflict have left Afghanistan strewn with landmines, unexploded mortars, rockets and homemade bombs -- and many are picked up by curious children.   Last month, seven children were killed and 10 more wounded in the eastern province of Laghman when a mortar shell exploded while they were playing with it.    According to the United Nations, 3,804 civilians -- including more than 900 children-- were killed in Afghanistan in 2018, with another 7,000 wounded. It was the deadliest year to date for civilians in Afghanistan's conflict.
Date: Tue, 16 Apr 2019 14:52:10 +0200

Kabul, April 16, 2019 (AFP) - Torrential rainstorms have lashed drought-stricken Afghanistan in recent days, bringing widespread flooding that has killed at least five people and washed away homes including in the capital Kabul, officials said Tuesday.   While some welcomed the wet weather after the punishing dry spell of recent years, residents complained about the lack of infrastructure and government assistance to help them clear up from the deluge.

Sixteen of Afghanistan's 34 provinces were hit in the past 24 hours, destroying or damaging hundreds of houses and sweeping away livestock, said Hashmat Bahaduri, a spokesman for Afghanistan's National Disaster Management Authority (ANDMA).   Hardest hit was Herat province in western Afghanistan, where at least five people were killed when their houses collapsed, Jilani Farhad, a spokesman for the local governor said.   Officials were also searching for 17 people whose minivan was swept away by flooding in the province's Obey district late Monday, Farhad added.    "There were women and children in the vehicle, we are searching but haven't found any sign of them yet," he said.

Extraordinary scenes played out in the capital, where the usually parched Kabul River swelled suddenly, bursting its banks in places and swamping surrounding streets and neighbourhoods with about one metre (three feet) of water in places.   Drug addicts who normally spend their time in the riverbed or hiding under bridges could be seen openly smoking opium at street level as water swirled around them.   By Tuesday, authorities were warning locals living along the river to be prepared to evacuate their homes as water levels surged.   Bahaduri said 113 houses had already been partially or completely destroyed in Kabul.

In the capital, a university student named Mujtaba bemoaned a lack of drainage canals, but others welcomed the rain.   "It is a bliss to have all this water and rain, we are thankful to God to have rain and get rid of the drought problems," Kabul resident Mansoor Majab told AFP.   Years of dry weather, combined with a booming population and wasteful consumption, have drained Kabul's water basin, forcing residents to drill ever-deeper wells.   This winter saw heavy snowfall across parts of Afghanistan, which had led to flash floods in the spring melt.   Over one hundred people had been killed as of March 28 due to flooding in Afghanistan so far this year, according to ANDMA.
Date: Mon 1 Apr 2019, 4:39 PM
Source: Xinhua Net [edited]
<http://www.xinhuanet.com/english/2019-04/01/c_137940693.htm>

A 2-year-old child was reported to have been affected by poliovirus despite receiving anti-polio vaccination in Afghanistan's southern province of Uruzgan [Oruzgan], a local official said on [Mon 1 Apr 2019].

The case was found affecting a baby-boy in Charchino district of the restive province, where he received 5 times anti-polio immunization, Khan Agha Miakhil, director of provincial public health department, told Xinhua.

The ongoing insurgency and conflicts have been hindering the efforts to stamp the infectious disease out in the mountainous country, he said.

The latest confirmed polio cases have risen to 2 so far this year [2019] while 20 polio cases were registered in the country last year [2018], according to health officials.
=======================
[With the addition of this case, it will bring the number of confirmed cases of polio reported from Afghanistan this year (2019) to 3; 2 prior cases were reported from Kandahar province. The total number of cases reported by Afghanistan during 2018 was 21, including 2 cases from Uruzgan (Oruzgan) province.

The history of 5 doses of polio vaccine is an unfortunate occurrence, but well observed in many countries due to competing infections for receptor sites. One wonders if this child had received the recommended 1 dose of IPV as part of the vaccinations. Below are a collection of references that can give an overview of the observations and studies done to address the issue of observed OPV "vaccine failure" and possible causes.

Uruzgan province shares it's southern border with Kandahar province where the prior cases of polio were reported this year (2019) (see
<http://ontheworldmap.com/afghanistan/political-map-of-afghanistan-with-provinces.html> for a map of Afghanistan showing provinces).

The HealthMap/ProMED map of Afghanistan can be found at:
<http://healthmap.org/promed/p/137>.

References discussing challenges in vaccine efficacy with OPV.
1. Nasir UN, Bandyopadhyay AS, Montagnani F, et al. Polio elimination in Nigeria: A review. Hum Vaccin Immunother. 2016 Mar 3;12(3):658-63. doi: 10.1080/http://promedmail.org/post/21645515.2015.1088617.
Full article available at:
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964709/>
2. Paul Y and Priya. Polio eradication in India: some observations. Vaccine. 2004 Oct 22;22(31-32):4144-8.
Abstract available at:
<https://www.ncbi.nlm.nih.gov/pubmed/15532129>
3. John TJ and Vashishtha VM. Eradicating poliomyelitis: India's journey from hyperendemic to polio-free status. Indian J Med Res. 2013 May;137(5):881-94.
Full article available at:
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734678/>
4. Taniuchi M, Platts-Mills JA, Begum S, et al. Impact of enterovirus and other enteric pathogens on oral polio and rotavirus vaccine performance in Bangladeshi infants. Vaccine. 2016 Jun 8;34(27):3068-3075. doi: 10.1016/j.vaccine.2016.04.080. Epub 2016 May 3.
Full article available at:
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912219/>
5. Saleem AF, Mach O, Quadri F, et al. Immunogenicity of poliovirus vaccines in chronically malnourished infants: a randomized controlled trial in Pakistan. Vaccine. 2015 Jun 4;33(24):2757-63. doi: 10.1016/j.vaccine.2015.04.055. Epub 2015 Apr 24.
Full article available at:
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447616/>
6. Patriarca PA. Poliomyelitis in selected African and Asian countries. Public Health Rev. 1993-1994;21(1-2):91-8.
Abstract available at:
<https://www.ncbi.nlm.nih.gov/pubmed/8041892>
7. John TJ. Experience with poliovaccines in the control of poliomyelitis in India. Public Health Rev. 1993-1994;21(1-2):83-90.
Abstract available at:
<https://www.ncbi.nlm.nih.gov/pubmed/8041891>
8. Balraj V, John TJ and Thomas M. Efficacy of oral poliovirus vaccine in rural communities of North Arcot District, India. Int J Epidemiol. 1990 Sep;19(3):711-4.
Abstract available at:
<https://www.ncbi.nlm.nih.gov/pubmed/2262269>
9. Sutter RW, Patriarca PA, Brogan S, et al. Outbreak of paralytic poliomyelitis in Oman: evidence for widespread transmission among fully vaccinated children. Lancet. 1991 Sep 21;338(8769):715-20.
Abstract available at:
<https://www.ncbi.nlm.nih.gov/pubmed/1679866>   - Mod.MPP]
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