Date: Mon 1 Jul 2019
Source: Eje Central Mexico [in Spanish, trans. ProMED Mod.MPP, edited]
<http://www.ejecentral.com.mx/alertan-por-enfermedad-viral-no-identificada-en-bolivia/>

An unknown disease that led to the death of an internal medicine physician and that has another 2 in serious condition has led to the activation of health protocols in Bolivia, requesting assistance from international medical teams in order to identify the aetiology of the disease, it was announced on Mon 1 Jul 2019 by the Minister of Health, Gabriela Montano.

Initial diagnostic tests indicated a "viral disease," but through the analysis of the physician who died and the 2 other professionals who are in intensive care, "they have discarded influenza and other viral diseases," such as dengue, according to Montano.

In the last hours, Montano increased the number of infected individuals to 5.  "We have 3 suspected cases in addition to the 1st 2 cases, the doctors; the other 3 are in the same hospital (in La Paz) as the original 2 cases," the Minister of Health said at a press conference.  "Two of the 3 new cases had contact with the 2 doctors who were infected. The 3rd person did not have contact with the professionals, but presented similar symptoms," said Montano.

In order to establish the origin of the disease, an infectious disease specialist from Brasil and another 2 specialists from Atlanta, United States [the Centers for Disease Control and Prevention, CDC], will help the national teams in the investigation.  The health authorities have not declared a state of epidemiologic emergency, while the representative from the Pan American Health Organization [PAHO/OPS] in Bolivia, Alfonso Tenorio, asked to follow protocols in order to "be calm."  "Bolivia has "the equipment and personnel fully trained in order to take the appropriate diagnostic steps, treatment, clinical management, and epidemiologic control," said Tenorio at a press conference.

As part of these protocols, the Ministry of Health ordered the mandatory use of masks and latex gloves in local hospitals.  At the end of last year [2018], Caranavi, the semitropical zone in the northeast of La Paz, where the deceased doctor was infected, reported a dengue outbreak that claimed the lives of 5 people.
Date: Mon 20 May 2019
Source: El Pais [in Spanish, trans. Mod.TY, edited]
<https://elpais.bo/reportan-un-nuevo-caso-de-hantavirus-en-padcaya/>

Tarija Departmental Health Services (SEDES) reported a new case of hantavirus [infection] in Padcaya municipality. The number of patients with this illness is within what is expected, because this season is when more people acquire the disease. Epidemiological surveillance is continuing in Arce province. The person who acquired this illness is male and is under medical care until his recuperation.

The head of the Epidemiological Unit of SEDES, Claudia Montenegro, stated that the patient is hospitalized in the San Juan de Dios Regional Hospital in Tarija awaiting his recuperation. The physician said that in Bermejo and Padcaya municipalities, the harvest of citrus fruit and sugar cane for production of sugar has begun, so there is a trend for the cases of this illness to increase. This is due to the large number of families that move to the countryside where the rodent (long tail) is present that transmits this disease [virus].

"In contrast to previous seasons, this year [2019], there were positives for this disease in Gran Chaco province, including fatalities," Montenegro commented. "Epidemiological surveillance there is being implemented, as well as in areas such as Padcaya and Bermejo."

The official explained that in these localities, the rodent that transmits the disease [virus] to families is present, and with agricultural activities, [people] move into places where this animal lives, and so new cases of patients with hantavirus [infections] are registered every year.

In order to prevent this illness, it is recommended that rodent control campaigns be done to reduce their populations, openings in houses be sealed, and that residents reduce the possibility for rodents to make nests within a radius of 30 meters [100 ft] around the house, and eliminate items that could attract these animals near the house (food, grain, garbage). Workers should employ protective measures during agricultural tasks and cleaning work.

Initial symptoms include fatigue, fever and muscle pain, especially in the thighs, hips and back. Also, patients may present with headache, dizziness, chills, nausea, vomiting, diarrhea and abdominal pain. [These symptoms may progress rapidly to respiratory difficulty requiring mechanical ventilation (hantavirus cardio pulmonary syndrome). Death can occur. - ProMED Mod.TY]
=====================
[The hantavirus involved in the above cases is not mentioned. Cases of hantavirus infections in Tarija department are not new. Tarija department is endemic for hantaviruses, and cases occur there sporadically. Last year (2018), there were 11 cases. The previouslyreported 2015 cases of hantavirus pulmonary syndrome (HPS) that occurred in Tarija department were confirmed. As noted in the previous comments, earlier cases of hantavirus pulmonary syndrome have been reported from tropical, lowland areas of Bolivia, including 7 cases in Tarija during 2014. The specific hantaviruses involved in these or previous cases in Bolivia were not given.

In the lowland Amazon Basin of Bolivia, the rodent hosts of the hantavirus that might be involved in these hantavirus pulmonary syndrome (HPS) cases, with their images, include the following: - Laguna Negra virus (_Calomys laucha_ <http://www.faunaparaguay.com/images/Calomys%20laucha%20enciso%2031aug2011.jpg> and _C. callosus_ <https://eee.uci.edu/clients/bjbecker/PlaguesandPeople/Calomyscallosusb.jpg>); - Bermejo (Chaco rice rat _Oligoryzomys chacoensis_ <http://www.faunaparaguay.com/oligorizomyschacoensis.html>); and - Oran (_O. longicaudatus_ <http://calphotos.berkeley.edu/imgs/512x768/0000_0000/0711/1203.jpeg>).

Since previous cases in Tarija department have occurred in Bermejo, perhaps Bermejo hantavirus was involved.

Dr. Jan Clement commented that there is a need to be able to differentiate Seoul (SEOV) as a causative agent, but that is hampered by the fact that most current commercial ELISA or WB formats do not contain (anymore) a SEOV antigen, so that a preliminary presumption of a hantavirus infection can even be missed in non-research laboratories (ibidem, and: Reynes J-M, Carli D, Bour J-B, Boudjeltia S, Dewilde A, Gerbier G, et al. Seoul virus infection in humans, France, 2014-2016. Emerg Infect Dis. 2017;23:973-7;  <https://wwwnc.cdc.gov/eid/article/23/6/16-0927_article>.

SEOV is widely distributed around the world in the brown rat and is likely found in Tarija department. - ProMED Mod.TY]

[HealthMap/ProMED map available at:
Tarija, Tarija, Bolivia: <http://healthmap.org/promed/p/12643>]
Date: Mon 29 Apr 2019
Source: El Deber [in Spanish, trans., ProMED Mod.TY, edited]
<https://www.eldeber.com.bo/santacruz/Reportan-un-caso-de-hantavirus-en-Postrervalle-20190428-9511.html>

A suspected case of [a] hantavirus [infection] in Postrervalle last week mobilized personnel of the medical centre of this municipality and the Office of Health of Vallegrande. The ill individual, a 17 year old, who works as a cowboy in the Mosqueras area, went to the [health] center, presenting with symptoms of [a] hantavirus [infection]. He was taken to Vallegrande where a corresponding chart was initiated and related tests were done that confirmed the 1st case of [a] hantavirus [infection] in the area. Due to the seriousness of the case, on [Fri 26 Apr 2019] the patient was transferred to Santa Cruz where he received treatment. It is believed that the patient was infected when he was in a rural property in Moroco, close to Mosqueras.

The Moroco - Mosqueras area is forested with high humidity due to the constant rains. There are several cattle ranches in the area. Rodrigo García, Chief of Health in Vallegrande, stated that they went immediately to the areas and established an [epidemiological] focal blockade and began to train people about management of the disease. Today [Mon 29 Apr 2019] a new team went into the place in order to verify the presence of long-tail rats that transmit the virus. A hantavirus outbreak was reported recently in [nearby] Tarija [department]. [Byline: Juan Carlos Aguilar F.]
========================
[The condition of the patient is reported as serious, prompting his transfer to Santa Cruz city where more advanced facilities are available. The seriousness of the case suggests that he may have developed hantavirus cardiopulmonary syndrome although no mention is made of the use of mechanical ventilation. The hantavirus involved in this case is not specified. The Moroco - Mosqueras area is an inter-Andean valley.

The report above indicates that it is forested area but the presence of cattle ranches indicates that extensive open areas of pasture must be present as well; making it difficult to determine which of several hantaviruses may be involved. Andes hantavirus has not been reported present in Bolivia.

In the lowland Amazon Basin of Bolivia, the rodent hosts of the hantavirus that might be involved in these cases, with their images, include the following:
- Laguna Negra virus (_Calomys laucha_ <http://www.faunaparaguay.com/images/Calomys%20laucha%20enciso%2031aug2011.jpg>
and _C. callosus_ <http://www.faunaparaguay.com/calomyscallosus.html>);
- Bermejo (Chaco rice rat _Oligoryzomys chacoensis_ <http://www.faunaparaguay.com/oligorizomyschacoensis.html>); and
- Oran (_O. longicaudatus_ <http://calphotos.berkeley.edu/imgs/512x768/0000_0000/0711/1203.jpeg>).

As Dr. Jan Clement pointed out previously, a battery of hantavirus diagnostic agents, including SEOV antigens is required to reach a definitive diagnosis. - ProMED Mod.TY]

[HealthMap/ProMED map available at: Bolivia: <http://healthmap.org/promed/p/5>]
Date: Thu 4 Apr 2019
Source: EJU TV [in Spanish, trans. Mod.TY, edited]
<https://eju.tv/2019/04/reportan-primer-fallecido-por-hantavirus-en-cochabamba/>

An 18-year-old young man died due to a hantavirus [infection], regional chief of Epidemiological Surveillance Ruben Castillo stated on Thursday [4 Apr 2019].  "We have registered on week 13 the death of a patient, an 18-year-old young man. Regrettably, this would be the 1st fatal hantavirus [infection] case notified for this year [2019]," he told the reporters, without giving the name of the victim.

According to Castillo, the patient went to a government health centre in the Villa Tunari municipality with symptoms of a febrile situation, apparently in a terminal state. He said that the preliminary information about the case determined that the youth had experienced a health problem for nearly a month. Also, he mentioned that the central Cochabamba department registered 7 laboratory-confirmed cases of hantavirus [infections]. "Of these, the 7 have emerged without any problems. Many had acquired the disease in their 'chaco' [the area around their village], as they call it, while working in an endemic area," he said.

The authority stated that the register of hantavirus [infection] cases in the Cochabamba tropics is related to an outbreak "that has us worried," so preventive tasks are being done for control.
=========================
[Unfortunately, the specific circumstances under which this youth or the previous 2019 cases acquired their infections is not mentioned. Presumably they were in contact with excreta from infected rodent hosts. Infected rodents shed the virus in faeces, urine, and saliva. Sporadic cases of hantavirus pulmonary syndrome occur in the Bolivian tropics, including Cochabamba department. The specific hantavirus involved in these or previous cases in 2013 or those in 2012, in Bolivia, is not given. In the lowland Amazon basin of Bolivia, the hantaviruses that are likely to be in tropical Cochabamba department that might be involved in these hantavirus pulmonary syndrome cases are Laguna Negra viruses with its rodent hosts, _Calomys laucha_, the small vesper mouse (<https://www.flickr.com/photos/cdtimm/4367939127/in/photolist-otqNuS-EwTizo-7DYQ8i-278Fjfq-owyXyD-osEZQs>), and _C. callosus_, the large vesper mouse (<http://www.faunaparaguay.com/calomyscallosus.html>), and Rio Mamore virus with _C. laucha_ and _Oligoryzomys microtis_, the small-eared pygmy rice rat (<https://www.reservacostanera.com.ar/wp-content/uploads/2011/02/colilargo-menor-oligoryzomys-flavescens2-JGV-e1298896507790.jpg>). - ProMED Mod.TY]

[HealthMap/ProMED-mail map:
Cochabamba, Bolivia: <http://healthmap.org/promed/p/55162>]
Date: Mon, 4 Feb 2019 21:12:01 +0100

La Paz, Feb 4, 2019 (AFP) - Two landslides in Bolivia left 14 people dead and seven missing, national police chief Romulo Delgado said on Monday.   Torrential rain caused the landslides on Saturday and Sunday on the road linking the capital La Paz to the northern town of Caranavi, the gateway to the Amazon rainforest.   President Evo Morales said on his Twitter account that helicopters were being used to transport 34 people who were injured to ocal hospitals.   He also posted pictures of himself at the scene alongside rescue teams.

Morales advised people to stay clear of the area and said humanitarian flights would be organized for emergency cases.   Saturday's landslide left 13 people dead, Delgado told the Panamericana private radio station, with Sunday's killing one person.   Pupils were due to return from their holidays on Monday but the local education authority in Caranavi postponed the start of the new school year by a week.   Bolivia's rainy season generally lasts from November to March with January and February often the wettest months.
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