Date: Wed 12 Feb 2020
Source: Teresina Municipal Health Foundation [in Portuguese, machine trans., edited]
<http://www.fms.teresina.pi.gov.br/noticia/3111/nota-informativa-melioidose>

Health Surveillance Directorate - Epidemiology Management
---------------------------------------------------------
Given the laboratory confirmation of 5 human cases of melioidosis (ICD-10 A24.4) that occurred in the state of Piaui in 2019 (including one death), the FMS Health Surveillance Directorate recommends Hospital Infection Control Commissions, to the Hospital Surveillance Centers, public and private microbiology laboratories, infectious disease specialists, pulmonologists, microbiologists, biochemists and physicians in general who are attentive, immediately report any case with a result of a culture of biological material (blood culture, urine culture, wound culture, tracheal secretion, cerebrospinal fluid, bronchial lavage, ascitic fluid, abscess, tissues, etc.) positive for the bacterium _Burkholderia pseudomallei_ (or _Burkholderia_ sp.). The notification must be made through the individual notification form of SINAN (available at <http://portalsinan.saude.gov.br/images/documentos/Agravos/NINDIV/Notificacao_Individual_v5.pdf>) and sent to the FMS, with the code appended ICD10: A24.4.

The positive bacterial isolate should be sent to the Central Public Health Laboratory, Dr. Costa Alvarenga (LACEN - PI) for confirmatory examination (Nested - PCR), upon registration in the GAL system (research: _Burkholderia pseudomallei_ sample: swab), in swab with Stuart's medium, at room temperature, along with a copy of the notification form.
======================
[This 2016 article (Limmathurotsakul D, Golding N, Dance DA, et al., Predicted global distribution of _Burkholderia pseudomallei_ and burden of melioidosis. Nat Microbiol. 2016;1:15008. <https://doi.org/10.1038/nmicrobiol.2015.8>; article available at <http://www.nature.com/articles/nmicrobiol20158.pdf>) for 2015 estimates the burden of melioidosis for the areas of major and some risk as follows:

Area / Population at risk in millions / Melioidosis cases in thousands / Melioidosis deaths in thousands
South Asia / 1525 / 73 / 42
East Asia and Pacific / 858 / 65 / 31
Sub-Saharan Africa / 602 / 24 / 15
Latin America and Caribbean / 246 / 2 / 1
Middle East and North Africa / 49 / less than 1 / less than 1

Although a classical infection in eastern Asia and northern Australia, cases have been acquired in Africa, the Caribbean basin, Central America, and, as in this case, South America. - ProMED Mod.LL]

[Brazil: <http://healthmap.org/promed/p/6>
Piaui, Brazil: <http://healthmap.org/promed/p/9666>]
Date: Wed, 5 Feb 2020 22:30:14 +0100 (MET)

Rio de Janeiro, Feb 5, 2020 (AFP) - A tourist who was robbed while vacationing in Rio de Janeiro posted a disgusted message online... only to have Brazil's national tourism board post it to its official Instagram account by mistake.   "Rio is such a beautiful city," begins the message posted by Instagram user @withlai -- and that is perhaps as far as the Brazilian Tourist Board's social media department read before clicking "share."   But the message continues: "Beautiful is not enough."   During a three-day stay in Rio, @withlai wrote, "my family and I were robbed and my nine-year-old sister witnessed a violent robbery. I can't recommend a visit to a city where I felt afraid of even leaving the apartment."

Embratur, as the tourism board is known, shared the message on its own Instagram account Tuesday evening, leaving it up long enough for the gaffe to go viral before deleting the post.  "This message was shared by mistake," Embratur said in a red-faced statement, adding that it was in fact working to "publicize the drop in violent crime (in Brazil) in 2019."   Rio, the port of entry for many of the millions of tourists who visit Brazil each year, is known for the breath-taking beauty of its sun-soaked beaches and emerald mountains, but also its violent crime.   Rio de Janeiro state, of which the city is the capital, registered nearly 4,000 murders and 120,500 muggings last year -- though that was a drop of 19 percent and eight percent, respectively.
Date: Mon 3 Feb 2020
Source: NSC Total [in Portuguese, trans. ProMED Mod.TY, edited]
<https://www.nsctotal.com.br/noticias/sc-confirma-novo-caso-de-febre-amarela-em-humano-e-o-segundo-de-2020>

Santa Catarina has another confirmed case [the 2nd] of yellow fever [YF] in humans. The information was confirmed by the secretary of state for health (SES) this Mon 3 Feb 2020. The patient is admitted to the Nereu Ramos Hospital, in Florianopolis, a reference infectious disease unit in Santa Catarina.

The diagnosis of the disease [as yellow fever] was confirmed by the Central Laboratory of Public Health (LACEN/SC)on Sunday [2 Feb 2020]. The 40 year old man, resident of Jaragua do Sul, in Planalto Norte of Santa Catarina, was not registered for the [YF] vaccination in the Information System of the National Program of Immunizations (SIPNI).

This is the 2nd case of human infection in the state and the 4th since 2019, when there was the 1st diagnosis in the state. Last year [2019], SC registered 2 deaths on account of the disease.

The 1st case of 2020:
The patient whose diagnosis was confirmed on 24 Jan [2020] remains hospitalized at Nereu Ramos Hospital, in Florianopolis. He is 47 years old and is a resident of the municipality of Sao Bento do Sul, also in Planalto Norte, and with no vaccine registration in the system.

Transmission:
Yellow fever is a serious disease, transmitted by mosquitoes in wildland areas and close to forests. Vaccination is the best way to protect oneself from the disease. The dose is free. To date, the state's vaccination coverage is 84%, below what the Ministry of Health recommends, which is to vaccinate at least 95% of the target population.

Symptoms:
Yellow fever is a rapidly progressive disease. The infection results
in the following symptoms:
- fever of up to 6 days duration;
- intense headache;
- abdominal pain;
- haemorrhagic manifestations;
- jaundice.

Monkey deaths:
On Mon 3 Feb 2020, SES also confirmed 2 more monkeys dead of yellow fever. The howlers were located in Corupa on 26 Dec 2019 and in Blumenau on 7 Jan of this year [2020].

In total, 9 monkeys dead of yellow fever were counted in 2019 (in Garuva, Joinville, Indaial, Jaragua do Sul, Sao Bento do Sul, and Corupa) and the 2 animals diagnosed with the disease in 2020 (Blumenau e Pomerode).  [byline: Clarissa Battistella]
====================
[The 2 human cases this year (2020) are due to YF virus spill-over from the sylvan (forest) transmission cycle. The dead monkeys indicate that the virus has been circulating in the state for over a year. It is important that the human population YF vaccination coverage reach the 95% goal set by the Ministry of Health. Vaccination is the only way to avoid these sylvan cases, since elimination of the forest YF virus transmission cycle is not feasible. - ProMED Mod.TY]

[HealthMap/ProMED map available at:
Santa Catarina, Brazil: <http://healthmap.org/promed/p/2975>]
Date: Wed 29 Jan 2020
Source: Globo.com [in Portuguese, trans. ProMED Mod.PMB, edited]
<https://g1.globo.com/pr/parana/noticia/2020/01/29/mortes-de-macacos-por-febre-amarela-aumentam-para-46-no-parana-indica-boletim.ghtml> [edited]

Monkey deaths due to yellow fever (YF) in Parana state have increased to 46 from 40 the previous week. According to a report issued by the state secretary of health, no case has been confirmed in humans so far, although 16 suspected cases are being investigated. Five of the new confirmed monkey cases were from Lapa, in the metropolitan region of Curitiba. This municipality had no previous record of dead monkeys due to YF. Another monkey death due to YF was in Antonio Olinto, in Southern Parana state. That city already had reported a confirmed case in monkeys.

The previous list of localities with records of monkey deaths due to YF is as follows: Castro: 11 Ponta Grossa: 8 Lapa: 5 Candido de Abreu, Sapopema, Teixeira Soares, Antonio Olinto, Ipiranga and Piraí do Sul: 2 Balsa Nova, Mandirituba, Quatro Barros, Rio Negro, Palmeira, Sao Joao do Triunfo, Imbituva, Mallet, Prudentópolis and Sao Mateus do Sul: 1. "The weekly newsletter is useful to monitor the outbreaks and alert on the presence of the virus in these localities", said the secretary of health, Beto Preto. Citizens of Parana state are being summoned to local units of health to receive vaccination against YF.

The vaccine is indicated for adults of up to 59 years old, and children from 9 months of age, with a booster at the age of 4 years. Pregnant and breastfeeding women, children up to 9 months of age and adults over 60, people with severe egg allergy or immunocompromised people should be vaccinated only after medical assessment.
===================
[The current expansion of YF in South America raises concern for public health and also about potential conservation problems for susceptible non-human primate species in the continent. The virus is endemic in much of central and northern South America, and makes sporadic incursions to southern areas of the continent, like the states of Santa Catarina, Parano and Rio Grande do Sul in Brazil, Misiones in Argentina, or Paraguay.

The YF virus was introduced into the Americas about 400 years ago, yet the complex interactions that were established after its introduction are far from being elucidated. There is need for more research on the eco-epidemiology of the disease in the continent, specifically on the role of each non-human primate species, and especially in the presence of the persistent anthropogenic global environmental change. - ProMED Mod.PMB]

[HealthMap/ProMED map available at: Brazil:
<http://healthmap.org/promed/p/6>]
Date: Tue 21 Jan 2020
Source: Outbreak News Today [edited]
<http://outbreaknewstoday.com/brazilian-hemorrhagic-fever-case-reported-in-sao-paulo-state-69791/>

For the 1st time in 20 years, Brazil health authorities are reporting a confirmed case of Brazilian haemorrhagic fever.  During this 20-year period, there were 4 cases in humans, 3 cases acquired in a sylvan environment in the state of Sao Paulo, and one due to infection in a laboratory environment in Para. The disease is considered to be extremely rare and highly lethal, and treatment is according to the patient's clinical condition and symptoms.

The disease incubation period is long (on average 7 to 21 days) and begins with fever, malaise, muscle pain, a rash on the body, sore throat, stomachache, and soreness behind the eyes, headache, dizziness, sensitivity to light, constipation, and bleeding from mucous membranes such as mouth and nose. As the disease progresses, there may be neurological impairment (drowsiness, mental confusion, changes in behavior and convulsion).

Between the onset of symptoms (30 Dec 2019) and death (11 Jan 2020), the current patient passed through 3 different hospitals in the municipalities of Eldorado, Pariquera-Acu and Sao Paulo, the last being the Hospital das Clinicas of the Faculty of Medicine of the University of Sao Paulo (HCFM USP). There was no history of international travel.

During his hospitalization, tests were carried out to identify diseases such as yellow fever, viral hepatitis, leptospirosis, dengue and Zika. However, the results were negative for these diseases. Complementary tests were carried out at the Special Techniques Laboratory of the Albert Einstein Hospital, which identified an arenavirus which causes Brazilian hemorrhagic fever. This result was confirmed by the Medical Research Laboratory of the Institute of Tropical Medicine, Hospital das Clinicas, USP Medical School, and Adolfo Lutz Institute.

In addition, SVS/MS has already communicated the fact to the World Health Organization and the Pan American Health Organization (WHO/PAHO), in accordance with established international protocols.

At this time, the source of the patient's infection has not been confirmed. What is known is that people contract the disease possibly through the inhalation of particles formed from the urine, feces and saliva of infected rodents. Transmission of arenaviruses from person to person can occur when there is very close and prolonged contact or in hospital environments, when personal protective equipment is not used, through contact with blood, urine, feces, saliva, vomit, semen and other secretions or excretions.

The employees of the hospitals through which the patient passed are being monitored and evaluated, as well as the family members of the confirmed case in Sao Paulo.

On Mon 20 Jan 2020, the Ministry of Health convened a meeting with representatives of all parties involved in the case: Secretariat of Sao Paulo, Hospital das Clinicas, Faculty of Medicine, University of Sao Paulo, Hospital Israelita Albert Einstein and the National Councils and State Health (Conass and Conasems). The purpose of the meeting was to verify the current scenario and the search and monitoring actions of people who had direct contact with the patient.

The Ministry of Health also offered support to the Sao Paulo Department of Health by sending a team of technicians to actively search for people who had contact with the patient and for environmental investigation.
--------------------------------
Communicated by:
ProMED-mail from HealthMap Alerts
<promed@promedmail.org>
and
Barry Atkinson <Barry.Atkinson@phe.gov.uk>
via Mary Marshall
mjm2020@googlemail.com
==================
[These are the 1st documented cases of Sabia virus infection in a long time. This confirmed case was an adult who lived in Sorocaba, Sao Paulo state.

The genome of the virus responsible for the disease was about 90% similar to the Sabia arenavirus according to Epidemiological Bulletin 03 (see below). One hopes that the environmental investigation will provide information about the circumstances under which the infection was acquired. A rodent reservoir was doubtless the direct or indirect source of the virus, as it is for other arenaviruses such as Machupo virus that causes Bolivian hemorrhagic fever. The rodent reservoir of the virus has not been identified.

The above report is a machine translation of an official report from the Brazil Ministry of Health
(<http://saude.gov.br/noticias/agencia-saude/46207-nota-informativa-arenavirus-caso-confirmado-de-febre-hemorragica-no-estado-de-sao-paulo>).

The Brazil Ministry of Health in its Epidemiological Bulletin No. 03 published an extensive overview of Sabia virus with a helpful epidemiological diagram (<http://portalarquivos2.saude.gov.br/images/pdf/2020/janeiro/20/Boletim-epidemiologico-SVS-03.pdf> in Portuguese). The bulletin provided the following references that report the original Sabia virus cases:

References:
Coimbra, Terezinha Lisieux M. et al. New arenavirus isolated in Brazil. The Lancet, v. 343, n. 8894, p. 391-392, 1994.
Gonzalez, Jean Paul J. et al. Genetic characterization and phylogeny of Sabia virus, an emergent pathogen in Brazil. Virology, v.221, n.2, p. 318-324, 1996. - Mod.TY

HealthMap/ProMED map available at:
Sao Paulo, Brazil: <http://healthmap.org/promed/p/45784>]
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