Dominican Republic
18 Mar 2019

(Probable and conf.) 624 cases. Municipalities most affected: Santo Domingo Este, Santo Domingo de Guzman, Barahona, and Santo Domingo Norte.
<https://infosurhoy.com/cocoon/saii/xhtml/en_GB/health/cases-of-dengue-and-malaria-increase-in-302-and-179-in-the-first-2-months-of-the-year/>
Date: Mon 31 Dec 2018
Source: Outbreak News [edited]
<http://outbreaknewstoday.com/rabies-4th-human-death-recorded-dominican-republic-year-56961/>

A 5-year-old boy died Saturday [29 Dec 2018] in a Santo Domingo hospital from rabies, the 4th such case of the year [2018] in the Dominican Republic, according to an El Comercio report (computer translated).

The child, who entered the Robert Reid Cabral Children's Hospital 10 days ago, remained in an induced coma, and yesterday his condition began to worsen, presenting respiratory, cerebral, and cardiac failures, according to a hospital spokesman.

The boy was bitten by a dog on 19 Nov 2018 in Pedernales, in the southwest of the Dominican Republic, and 10 days later he was subjected to an anti-rabies vaccination scheme, receiving 4 doses.

This death follows a 6-year-old child who died on 14 Dec 2018.
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[We do not know what kind of wound care this child received prior to getting the post exposure prophylaxis (PEP). Neither does this article tell us the location of the bite on the body. This article also does not mention rabies immunoglobulin (RIG).

We are sorry for the family and the loss of this child. Sadly, this is an example of the urgency and necessity to get medical attention very quickly.

According to the US Center for Disease Control (CDC),

- The rabies virus is transmitted through saliva or brain/nervous system tissue. You can only get rabies by coming in contact with these specific bodily excretions and tissues.

- It's important to remember that rabies is a medical urgency but not an emergency. Decisions should not be delayed.

- Wash any wounds immediately. One of the most effective ways to decrease the chance for infection is to wash the wound thoroughly with soap and water.

- See your doctor for attention for any trauma due to an animal attack before considering the need for rabies vaccination.

- Your doctor, possibly in consultation with your state or local health department, will decide if you need a rabies vaccination. Decisions to start vaccination, known as post exposure prophylaxis (PEP), will be based on your type of exposure and the animal you were exposed to, as well as laboratory and surveillance information for the geographic area where the exposure occurred.

- In the USA, post exposure prophylaxis consists of a regimen of one dose of immune globulin and 4 doses of rabies vaccine over a 14-day period. Rabies immune globulin and the 1st dose of rabies vaccine should be given by your healthcare provider as soon as possible after exposure. Additional doses or rabies vaccine should be given on days 3, 7, and 14 after the 1st vaccination. Current vaccines are relatively painless and are given in your arm, like a flu or tetanus vaccine (<https://www.cdc.gov/rabies/exposure/index.html>). - ProMED Mod.TG]

[HealthMap/ProMED-mail map:
Pedernales, Pedernales, Dominican Republic:
<http://healthmap.org/promed/p/2198>]
Date: Sat 1 Dec 2018
Sources:  <http://outbreaknewstoday.com/dominican-republic-reports-increase-malaria-45684/>

Health officials in the Dominican Republic are reporting an increase in malaria cases in 2018.

According to a Diario Salud report [computer translated], 438 cases have been reported year to date compared to just 360 during the same period in 2017.

92 percent of the malaria cases were due to _Plasmodium falciparum_ and the remainder were _P. vivax_ or mixed infections.

One death has been reported.

In the last month, 31 cases of malaria have been reported, of these, 27 are indigenous and 4 are imported, 3 from Venezuela and one from Guyana.
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[Autochthonous malaria has been reported from the Dominican Republic over the past 15 years, documented especially by malaria in returning visitors. The main problem is the proximity to Haiti, where malaria is endemic, and asymptomatic carriers from Haiti start local transmission in the Dominican Republic. One solution could be screening upon arrival, or if that is not possible, a course of treatment for instance with artemether/lumefantrine upon arrival, ending with a single dose of primaquine to inactivate gametocytes, as recommended by WHO (Policy brief on single-dose primaquine as a gametocytocide in _Plasmodium falciparum_ malaria. WHO, Geneva January 2015; <https://www.who.int/malaria/publications/atoz/policy-brief-single-dose-primaquine-pf/en/>). - ProMED Mod.EP]

[HealthMap/ProMED map available at:
Dominican Republic: <http://healthmap.org/promed/p/24>]
Date: Sun 16 Sep 2018
Source: Listin Diario, Republica Dominicana [in Spanish, trans. ProMED Mod.MPP, edited]
<https://listindiario.com/la-republica/2018/09/16/533361/sistema-capta-63-casos-de-malaria-en-las-ultimas-cuatro-semanas>

At least 63 confirmed cases of malaria have been reported through the surveillance system in the last 4 weeks, with 75% corresponding to the localized focus in the neighbourhoods of Santa Domingo West.

Until the beginning of September 2018, 294 cases were reported in the entire country, with the neighbourhoods of La Cienaga, Hato Nuevo, Caballona, and Manoguayabo, in Santo Domingo Oeste, and Las Mercedes in Los Alcarrizos presenting the highest incidence of this febrile disease, transmitted by the bite of the _Anopheles_ mosquito, which breeds in standing and dirty water, especially where there is vegetation.

In the past week, the surveillance system detected 25 confirmed cases, all autochthonous, including 17 men and 8 women with ages ranging from 13 to 62 years, according to the data contained in the epidemiologic bulletin for week 35.  [Communicated by:  Jaime R. Torres torresj@email.com]
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[This is a large outbreak of introduced malaria with an increasing number of local cases. It is important to apply vector control and early case detection and treatment. Treatment should include a single dose of primaquine to block transmission.

An outbreak of introduced _Plasmodium vivax_ malaria in Greece in 2011 to 2012 was terminated by applying mass drug administration to the migrant worker population from _P. vivax_ endemic countries (Tseroni M, Baka A, Kapizioni C, et al. Prevention of malaria resurgence in Greece through the association of mass drug administration (MDA) to immigrants from malaria-endemic regions and standard control measures. PLoS Negl Trop Dis. 2015; 9(11): e0004215. doi: 10.1371/journal.pntd.0004215;  <https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0004215>).

The malaria in this outbreak is almost certainly introduced by migrants from Haiti, and a mass drug administration program similar to the program used in Greece would eliminate a reservoir of malaria in semi-immune and asymptomatic individuals. - ProMed Mod.EP]

[HealthMap/ProMED map available at:
Santo Domingo, Distrito Nacional, Dominican Republic:
<http://healthmap.org/promed/p/4842>]
Date: Tue 31 Jul 2018
Source: elCaribe [in Spanish, machine trans., edited]
<https://www.elcaribe.com.do/2018/07/31/boletin-registra-33-casos-de-malaria-en-santo-domingo-oeste/>

The Santo Domingo Oeste municipality [Dominican Republic] has registered 66 percent of all malaria cases registered in the country so far this year [2018], according to the most recent epidemiological bulletin. In the week [8-14 Jul 2018], 8 cases were detected confirmed, of which, 7 are indigenous and one imported, this one a 35-year-old Venezuelan man in whom _Plasmodium vivax_ was detected.

The indigenous cases come from the transmission focus in the La Cienaga neighbourhood in Santo Domingo Oeste. During the last 4 weeks, 50 cases have been confirmed, of which 33 reside in the Santo Domingo Oeste municipality, for a total of 190 cases accumulated up to week 28 [week of 8 Jul 2018]. The highest frequency and accumulated incidence rate is registered in the Santo Domingo province.

Malaria is transmitted through the bite of anopheline mosquitoes infected, and cause high fevers, chills, flu-like symptoms, and anaemia. The health authorities consider that the resurgence of cases is related to the rains caused by the remnants of the storm Tropical Beryl [9 Jul 2018], which left the most rainfall in the District National, Santo Domingo, and San Cristobal.

In this regard, it is recommended to strengthen surveillance to detect outbreaks in these 3 territories. [Byline: Mar­a Teresa Morel]
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[Autochthonous malaria transmission has been described regularly in the Dominican Republic over the past 15 years.  The main explanation is that people with malaria from Haiti visit and work in the Dominican Republic, initiating local transmission. This has also resulted in visitors from North America and Europe returning with malaria from tourist resorts in the Dominican Republic.

The CDC recommends malaria chemoprophylaxis to the province of Santo Domingo
(<https://wwwnc.cdc.gov/travel/yellowbook/2018/infectious-diseases-related-to-travel/yellow-fever-malaria-information-by-country/dominican-republic#seldyfm879>). - ProMED Mod.EP]

[HealthMap/ProMED-mail map of Santo Domingo Oeste, Dominican Republic:
<http://healthmap.org/promed/p/40654>]
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