Date: Fri 21 Jun 2019
From: Lucille Blumberg <firstname.lastname@example.org> [edited]
East African trypanosomiasis (EAT) has been confirmed on a 36-year-old teacher, a USA citizen who has been in Malawi for the past 14 years and is currently resident in Lilongwe.
He went fishing in the Nkhotakota Wildlife Reserve at the beginning of June 2019, but did not recall seeing any tsetse flies or experiencing any tsetse bites. EAT is well documented in the reserve.
Twelve days later, he developed an acute febrile illness, initially managed as a bacterial infection and then as malaria -- 2 rapid diagnostic tests [RDT] for malaria were negative, but gametocytes were reported on a smear. The doctor was concerned by the negative malaria RDT results and non-response to IVI [intravenous infusion] artesunate.
The blood smear was reviewed and trypomastigotes seen. Although suramin treatment was accessed from a hospital further north in Kasungu [Central region of Malawi], the decision was made to transfer the patient to a Johannesburg [South Africa] hospital on [19 Jun 2019] because of the decreasing platelet count.
In Johannesburg EAT (parasitaemia 5000/microL) was confirmed and the following complications have been noted: hepatic dysfunction with clinical jaundice, thrombocytopenia (platelet count 15 x 109/L) with a petechial rash, mild renal dysfunction, and early ARDS [adult respiratory distress syndrome]. There is no evidence of a trypanosomal chancre (present in about 80% of patients with EAT), his mental state was normal, and the patient was hemodynamically stable with no evidence of a myocarditis.
Suramin (test and 1st doses) has been administered with good response. A CSF [cerebrospinal fluid] examination will be conducted once the peripheral parasitaemia has cleared and the platelet count has increased.
Lucille Blumberg and John Frean
Centre for Emerging Zoonotic and Parasitic Diseases
National Institute for Communicable Diseases -- a GeoSentinel Site
PRF Building, 1 Modderfontein Rd, Sandringham
Kim Roberg and Brian Levy, physicians (Infectious Diseases and Critical Care) Johannesburg, South Africa
[The Nkhotakota Wildlife Reserve in northern Malawi is the largest and oldest of the national parks in the country
African trypanosomiasis is a zoonotic disease with a reservoir in wild game animals and is a risk throughout game parks in Africa including Malawi. More information can be found on the FAO (Food and Agricultural Organization of the United Nations) website on African trypanosomiasis at <http://www.fao.org/paat/en/
The case story presented here shows that trypanosomiasis is a differential diagnosis to malaria and indeed haemorrhagic fever in endemic areas. Thus, patients with a negative malaria blood film should be suspected and investigated for trypanosomiasis, also called African sleeping sickness. - ProMED Mod.EP]
[HealthMap/ProMED-mail map of Malawi: