Date: Mon, 2 Mar 2020 13:14:29 +0100 (MET)

Abuja, March 2, 2020 (AFP) - Nigeria is monitoring 58 people who had contact with an Italian man infected with the new coronavirus, the health minister said Monday, as officials scrambled to stop the disease spreading.    Africa's most populous country on Friday confirmed the first case of the virus in sub-Saharan Africa after the patient was diagnosed in the economic hub Lagos.

The Italian had arrived from Milan on a business trip a week ago and travelled to a company in neighbouring Ogun state before being diagnosed.    He was quarantined at the Infectious Disease Hospital in the sprawling city of 20 million and was responding to treatment.

Authorities launched efforts to track down all those he might have had contact with.    "Currently, the contacts of the index case are identified as 19 contacts in Lagos and 39 contacts in Ogun state," Health Minister Osagie Ehanire told reporters in Abuja, the nation's capital.    "We are in touch with these contacts who are under supervised self-isolation and the states have provided them with temperaure monitoring tools," he said, adding that they would be under observation for at least 14 days.

The minister said the measure was to control the spread of the disease, which has killed more than 3,000 people, mostly in China where it broke out late last year.    "Contact tracing is a specialised activity that is done by experts -- epidemiologists who know exactly what questions to ask and how to track people down.    "And the purpose is to know if you have an index case, who has been in contact with, and what is the likelihood that that person contracted the disease," he said.

Ehanire said health officials would continue to hunt for more contacts with the Italian, adding that the 156 passengers on the same flight with him when he came to Nigeria were also being traced.    "We cannot give you a specific figure because it is a continuing process," he added.   Nigeria is viewed as highly vulnerable to viral spread given its weak health system and high population density.    Prior to the case in Nigeria, the first in sub-saharan Africa, there had been just two cases on the continent -- in Egypt and Algeria.
Date: Thu, 20 Feb 2020 10:28:16 +0100 (MET)

Lagos, Feb 20, 2020 (AFP) - An outbreak of Lassa in Nigeria has killed 103 people this year, health authorities said, as the first confirmed case was reported in the economic hub Lagos.    "Cumulatively from week 1 to week 07, 2020, 103 deaths have been reported with a case fatality rate of 17.6%," said the Nigeria Centre for Disease Control (NCDC) in its latest statistics on the virus released on Wednesday.    The overall number of confirmed cases rose by 115 last week to a total of 586 across the country.

Separately, health authorities in Lagos, Nigeria's most populous city with 20 million inhabitants, said an infected person was diagnosed there on February 17 and being treated in isolation in hospital.    "Sixty-three people that may have been in contact with the patient and who may have been infected in the process have been identified and are being monitored," the state government wrote on Twitter on Thursday.

Endemic to Nigeria, Lassa fever belongs to the same family as the Ebola and Marburg viruses, but is much less deadly.   The disease is spread by contact with rat faeces or urine or the bodily fluids of an infected person.    The majority of those infected do not show symptoms but the disease can go on to cause severe bleeding and organ failure in about 20 percent of cases.

An outbreak of Lassa fever killed some 170 people around Nigeria last year.     The number of cases usually climbs around the start of the year linked to the dry season.   While the overall number of confirmed cases and deaths is up this year on the same period in 2019, the mortality rate is lower.    Twenty health workers across the country have been confirmed as contracting the disease so far in 2020.    The virus takes its name from the town of Lassa in northern Nigeria, where it was first identified in 1969.
Date: Fri 31 Jan 2020
Source: Nigeria CDC Situation report, yellow fever [edited]
<https://ncdc.gov.ng/themes/common/files/sitreps/59379981b136548902a46c52526e80be.pdf>

Highlights
----------
In this reporting period:
- A total of 139 suspected cases were reported in 90 LGAs across 27 states
- All 139 suspected cases had blood samples collected
- 2 presumptive positive and 1 inconclusive case were reported; the inconclusive case was reported from Katsina State
- No confirmed case was recorded from Institute Pasteur Dakar
- No death was recorded from all the cases reported

Yellow fever response activities are being coordinated by the multi-agency yellow fever Technical Working Group (YF TWG).

Off-site support is being provided to all states.

Yellow fever preventive mass vaccination (PMVC) campaigns are planned for implementation in Oyo, Delta, Benue, Osun, Bauchi and Borno in the 3rd and 4th quarters.

Graphs and a map accessible at the above URL;
Figure 1 [graph]: Epidemic Curve of All Cases of Yellow Fever in Nigeria from Week 1 - Week 5, 31 Jan 2020
Figure 2 [graph]: Trends of Confirmed Cases in Nigeria - 2018, 2019 and January 2020
Figure 3 [graph]: Yellow fever Attack rate by State in Nigeria from Week 1 - Week 5, 31 Jan 2020
Figure 4: Map of Nigeria Showing States with Suspected and Presumptive confirmed Cases from Week 1 - Week 5, 31 Jan 2020
====================
[This report is not clear about the number of confirmed yellow fever (YF) cases that there have been in Nigeria this year (2020). The above report indicates that there are 139 suspected cases and all have had blood samples taken but does not state if all samples have been tested for YF by the Institute Pasteur in Dakar. The report does state that no confirmed case was recorded by the Institute Pasteur Dakar. The report states that 2 cases are presumptive and 1 is inconclusive. The graph in Figure 2 shows no confirmed cases in 2020.

It is curious that a 19 Jan 2020 report indicated that there were 141 suspected yellow fever cases in Jos North, Wase, Bassa, Kanam and Riyom Local Governments of Plateau State, of which 25 cases had been confirmed (see Yellow fever - Africa (02): Nigeria (PL) http://promedmail.org/post/20200121.6903167). A 29 Dec 2019 The World Health Organization (WHO) report confirmed 13 cases of yellow fever (YF), with 3 deaths in 4 local government areas of Plateau State (see Yellow fever - Africa (01): Nigeria (PL) http://promedmail.org/post/20200101.6862783). It is possible that all of these Plateau state cases occurred in 2019 and, hence, are not included in the above 2020 report which does not mention any cases in Plateau state. - ProMED Mod.TY]

[HealthMap/ProMED map available at:
Nigeria: <http://healthmap.org/promed/p/62>]
Date: Wed 29 Jan 2020
Source: Daily Trust [edited]
<https://www.dailytrust.com.ng/just-in-unknown-illness-claims-four-lives-in-benue-community.html>

An unknown illness has reportedly claimed the lives of 4 persons in the rural community of Oye-Obi in Obi local government area of Benue state. The president-elect, Igede National Youths Council, Andyson Iji Egbodo, who raised the alarm on Wednesday night [29 Jan 2020] on behalf of the villagers, told our correspondent by telephone that 15 more people with the same symptoms are already hospitalised in the affected community.

"The sickness has so far killed 4 persons in 2 weeks. The 4 victims developed the same symptoms -- headache, fever, diarrhoea, vomiting, stomach-ache, weakness of the body, and swollen stomach -- and died alike," he said. Egbodo added that about 6 more persons who as at Wednesday [29 Jan 2020] were developing the same symptoms have been moved to the General Hospital in Oju, while the remaining 9 that made up the total of 15 on admission are kept at a private dispensary.

The youth leader who suspected the illness to be Lassa fever has appealed as a matter of urgency to the state government as well as relevant health authorities to come to the aid of the boundary settlement people before the illness causes further harm.

When contacted, the state's epidemiologist, Dr. Sam Ngishe, confirmed the death of the 4 people, adding that the health authorities were alerted to the situation a few hours ago.

Ngishe said an emergency response team from the state's Ministry of Health had been immediately sent to the area to contain the situation, while 3 of the patients are expected to be moved to Makurdi on Thursday [30 Jan 2020] for further investigation. The epidemiologist added that until investigation on the matter is completed, he cannot immediately confirm the nature of the illness, as there were already 2 sides to the rumour of possible causes of the deaths. He explained that there were reports that the community's source of drinking water was poisoned with Gamalin, and those affected may have consumed fish taken from the pond, while another side of the story suggested that the people who died presented symptoms of fever. "We can't base our findings yet on these rumours. We'll have to investigate it, and by tomorrow [Thu 30 Jan 2020], we will able to tell the press what exactly the challenge might be," Ngishe said.  [Byline: Hope Abah Emmanuel, Makurdi]
=======================
[It is difficult to speculate on the etiology of the illnesses that these individuals were suffering. Although no hemorrhaging was reported, the other reported symptoms are compatible with Lassa fever, and this is the season when Lassa fever virus transmission is highest (see <Lassa fever - West Africa (07): Nigeria http://promedmail.org/post/20200129.6930926>). The epidemiological investigations may provide additional information. Laboratory testing of samples from the affected individuals should provide information that may indicate the etiology involved. - ProMED Mod.TY]

[This article mentions "..community's source of drinking water was poisoned with Gamalin and those affected may have consumed fish taken from the pond.."

Gamalin, more often spelled Gammallin is also known as Lindane, which is a gamma-hexachlorocyclohexane, also called gammaxene. It is an organochlorine chemical and has been used as an insecticide and as a treatment for lice and scabies.

Lindane, a neurotoxin, interfering with nervous system, and can also affect the function of the liver and/or kidneys. It may be a carcinogen but has not specifically been designated as such. It has been classified as moderately hazardous by the World health Organization.

Being exposed to large amounts of lindane may be harmful to the neurological system. Clinical signs may include headache, dizziness, and seizures/convulsions, but rarely does it cause death.

Many of the organochlorines are banned in many areas because of the neurological effects, with the exception of the specific use of treating scabies.

Although the article specifically mentions lindane (organochlorine) the clinical signs mentioned in the article (headache, fever, diarrhoea, vomiting, stomach ache, weakness of the body and swollen stomach and death) do not mention the overwhelming clinical sign of most organochlorines, which is over-stimulation of the CNS, with seizures beginning approximately 1 hour post ingestion.

We look with interest to the outcome of the investigation and learning what affected these individuals. - ProMED Mod.TG]

[Maps of Nigeria:
<http://www.un.org/Depts/Cartographic/map/profile/nigeria.pdf> and
<http://healthmap.org/promed/p/62>]
Date: Thu 30 Jan 2020
Source: All Africa [edited]
<https://allafrica.com/stories/202001300085.html>

An epidemiologist in Ondo state, Dr. Stephen Fagbemi, on Wednesday [29 Jan 2020] said the death toll from Lassa fever has risen to 20. The casualty figure was also corroborated by the state commissioner for health, Dr. Wahab Adegbenro.

A total of 112 confirmed cases were said to have been recorded in the state so far just as 5 local government areas [LGAs] of the state were said to have been hit by the disease.

The affected council areas include Akoko South West, Ose, Owo, Akure South, and Ondo West LGAs, while the victims were transferred to the Federal Medical Centre, Owo, and a treatment centre in Akure.

The state government last week revealed that 16 deaths had been recorded from the disease out of the 100 cases that were confirmed.

Adegbenro said the figure of the victims rose as a result of the influx of some victims from the neighbouring states to Ondo due to free treatment in the state.

"We are having the high figure because Ondo state is the only state that the treatment of Lassa fever is free of charge. I think we are having people coming from other areas to access the free treatment," he said.

The commissioner, who addressed journalists on World Neglected Tropical Diseases [NTD] Day, held on 20 Jan [2020], said the state has been mapped for the various neglected tropical diseases [NTDs]. Some of these, he said, include onchocerciasis, lymphatic filariasis, leishmaniasis, soil-transmitted helminths, schistosomiasis, and human African trypanosomiasis.

He explained that the "mapping result indicates that the state has overlapping endemicity for 4 preventive chemotherapy NTDs: the onchocerciasis, lymphatic filariasis, schistosomiasis, and schistosomiasis."

He said the government was being proactive in tacking the diseases as the government had begun the distribution of the preventive chemotherapy for the NTD, adding that the distribution varies across the communities and LGAs in the state.

"The scourge of NTDs were also being addressed through mass awareness created through different print and electronic media along with specific mass administration of medicines in the endemic areas," he stated.

The commissioner also noted that the World Health Organisation had targeted most of the preventive chemotherapy of the NTDs for elimination by 2030 "in line with the Millennium Development Goal 3."  [Byline: James Sowole]
===========================
[The number of Lassa fever cases in Ondo state is increasing, although not all may have originated in that state, as mentioned above. The most recent Nigeria CDC Lassa fever update indicates that Ondo and Edo states have the majority of cases (see Lassa fever - West Africa (07): Nigeria http://promedmail.org/post/20200129.6930926). Nigeria is now well into the period of the year when more cases usually occur, as illustrated in the graph in Figure 6 (at the source URL in above-mentioned post). There has been a peak in case numbers between weeks 1 and 11 (January-March) over the past 3 years, and it appears that this will be the case again this year (2020).
Transmission of LF virus occurs when individuals are in contact with rodent reservoir host excreta or are within healthcare facilities. The above report does not mention the circumstances under which the individuals acquired their infections. Presumably, it was from contact with the rodent reservoir or their excreta. Public education at the village level about the risks these rodents present and ways to avoid exposure is the best way to prevent most cases.

Images of the rodent reservoirs of Lassa fever virus:
_Mastomys natalensis_:
<https://www.inaturalist.org/taxa/45326-Mastomys-natalensis>
_Mastomys erythroleucus_ and _Hylomyscus pamfi_:
<http://punchng.com/nigerias-large-rat-population-threatens-lassa-fever-war/>

Maps of Nigeria:
<http://www.un.org/Depts/Cartographic/map/profile/nigeria.pdf> and
<http://healthmap.org/promed/p/62>  - ProMed Mod.TY]
More ...