Date: Sun 25 Aug 2019
Source: Nigeria CDC Weekly Epidemiological Report for week 34 [edited]
<https://ncdc.gov.ng/reports/207/2019-august-week-34>

Lassa Fever
-----------
Key points
- There were 78 suspected cases of Lassa Fever (LF) reported from 16 LGAs in 13 states (Edo - 51, Ondo - 9, Ebonyi - 5, Bauchi - 4, Nasarawa - 1, Taraba - 1, Kwara - 1, Gombe - 1, Kaduna - 1, Kogi - 1, Delta - 1, Rivers - 1 & Cross River - 1). There were 6 confirmed cases and no death was recorded
- In the reporting, one new health care worker was infected in Ebonyi state. A total of 19 health care workers have been infected since the onset of the outbreak

Actions
To date:
- National LF multi-partner, multi-sectoral Technical Working Group
(TWG) continues to coordinate the response activities at all levels
- Implementation of targeted risk communication and enhanced surveillance activities in affected states

Planned:
- Conduct a National After Action Review (AAR) retreat
- LF treatment centres assessment visit to Bauchi and Plateau states
- Finalise LF psychosocial guideline

Figure 1 [graph]. Number of suspected and confirmed cases Nigeria week 1- 34, 2019
Figure 2 [map]. Number of confirmed Lassa fever cases by state Nigeria Week 34, 2019
=========================
[As of 14 Jul 2019, from 1 Jan - 14 Jul 2019, a total of 3043 suspected cases have been reported from 22 states. Of these, 622 were confirmed positive, 17 probable cases. The above report indicates that there are 78 new suspected cases and 6 new confirmed during week 34. A total case count since 1 Jan 2019 is not given. Cases remain fairly wide spread geographically, with cases reported from 16 LGAs in 13 states. The occurrence of new cases indicates that Lassa fever (LF) virus transmission is continuing although Nigeria should be beyond the period of the year when more cases usually occur.

Transmission of LF virus occurs when individuals are in contact with rodent reservoir hosts' excreta or are within healthcare facilities. It would be interesting to know whether the prevalence of Lassa fever virus has been increasing in populations of rodent hosts in areas where human cases are occurring.

Images of the rodent reservoirs of Lassa fever virus:
_Mastomys natalensis_:
<https://www.inaturalist.org/taxa/45326-Mastomys-natalensis>
_Mastomys erythroleucus_ and _Hylomyscus pamfi_:
<http://punchng.com/nigerias-large-rat-population-threatens-lassa-fever-war/>

There is no mention in the plans above of public education for avoidance of contact with these rodents and their excreta. - ProMED Mod. TY]

[Maps of Nigeria:
<http://www.un.org/Depts/Cartographic/map/profile/nigeria.pdf> and
<http://healthmap.org/promed/p/62>]
Date: Sun 15 Sep 2019
Source: This Day [edited]
<https://www.thisdaylive.com/index.php/2019/09/15/yellow-fever-bauchi-to-immunise-500000-disinfect-communities/>

The Bauchi State Government yesterday [Sat 14 Sep 2019] unveiled anti-yellow fever campaign to immunise 500,000 people in Alkaleri and Tafawa Balewa Local Government Areas to curtail the spread of the acute viral haemorrhagic disease transmitted by infected mosquitoes.

The state governor, Senator Bala Mohammed disclosed the plan at the unveiling of aerial spray of Quella birds, mosquitoes and reactive vaccination in response to yellow fever at the Sir Abubakar Tafawa Balewa International Airport, Bauchi.

Mohammed explained that the exercise, which involved spray of affected areas and vaccination against yellow fever, was a testimony of the commitment of the administration to health issues and response to emergency.

The governor stated that the vaccination would be conducted for people in high risks areas of Alkaleri and Tafawa Balewa LGAs, thereby urging people living there to come forward for the vaccination.

He commended traditional rulers in the state particularly the Emir of Dass, Alhaji Bilyaminu Othman for creating awareness among their subjects regarding the outbreak of yellow fever in parts of the state. He also commended the development partners including the World Health Organisation (WHO), the United Nations Children's Fund (UNICEF) and the Federal Ministry of Health, among others for supporting the state.

On the aerial spray of Quella birds, the governor lamented the menace of the birds on farm produce. He, however, commended the Federal Ministry of Agriculture and Rural Development for providing aircraft needed to spray 38 rusty[?] sites. [The Quella birds mentioned are probably red-billed quela, _Quela quela_ that have nothing to do with yellow fever virus maintenance, movement or transmission].

He said: "The aircraft came at the needed time. We are leveraging on the federal government's gesture to use the aircraft to spray the areas where the vector carrying yellow fever are believed to be."

He added that his administration "will continue to give priority to health and preventive medicine, hence the declaration of state of emergency in the health sector and increase of the health budget to 16 % in the 2019 budget.

He said as a demonstration of the commitment of his administration to the sector, the state government had paid N200 million [USD 554,017] as counterpart funds to the Melinda and Bill Gates and the Dangote Foundation, UNICEF and USAID.  "Despite the state of emergency to reposition the health sector, indices such as the rates of infant and maternal mortality are worrisome. I have therefore given marching order to the Commissioner for Health to convene a health summit to enable us to know the gaps."

Earlier in his remarks, the Director of the state Primary Health Care Developments, Dr. Rilwanu Mohammed praised the state government for the prompt response to address the acute viral haemorrhagic disease transmitted by infected mosquitoes.  [Byline: Segun Awofadeji]
==========================
[The above report does not mention if there were more than the one confirmed and one suspected YF cases that were acquired in the Yankari Game Reserve, Bauchi state [see Undiagnosed illness - Nigeria (02): (BO) fatal, poss. link to game reserve, RFI http://promedmail.org/post/20190906.6660123]. There were 16 college girls who also visited this game reserve and became ill, 4 of whom died. Samples were sent for laboratory diagnosis of these girl's illnesses but no results have been announced so it is still not known if YF was involved. However, the occurrence of a YF case and possibly another in the Yankari Game Reserve that the students also visited, indicates that YF virus was circulating there and there were additional YF cases in the state. Vaccination of 500,000 people in the state will provide [better] longer-term protection against YF than spraying will. - ProMED Mod.TY]

[Maps of Nigeria:
<https://maps-nigeria.com/img/1200/map-of-nigeria-showing-the-geopolitical-zones.jpg>
and <http://healthmap.org/promed/p/62>. - ProMED Mod.TY]

[HealthMap/ProMED map available at:
Bauchi State, Nigeria: <http://healthmap.org/promed/p/3741>]
Date: Sat 7 Sep 2019
Source: WHO Africa [edited]
<https://www.afro.who.int/news/nigeria-launches-yellow-fever-vaccination-reactive-campaign-contain-outbreak-ebonyi-state?country=979&name=Nigeria>

The federal government, in collaboration with the World Health Organization (WHO), Gavi, the Vaccine Alliance, and partners, is launching a yellow fever (YF) reactive vaccination campaign in 3 states to help control an expanding YF outbreak in Nigeria identified in Ebonyi.

The 10-day campaign (7-16 Sep 2019), to be implemented in parts of Ebonyi (3 LGAs), Benue (2 LGAs) and Cross River (1 LGA) States, targets vaccination of 1.6 million people (aged 9 months to 44 years old) to contain the outbreak in affected areas. The campaign, supported by Gavi, will use 1 802 044 vaccine doses provided by the International Coordination Group (ICG) on Vaccine Provision, funded by Gavi, the Vaccine Alliance.

"This vaccination campaign will be a crucial activity to stop the spread of the outbreak and ensure that all people at highest risk are safe," says Dr Clement Peter, Officer in Charge, WHO Nigeria. "We encourage all eligible persons in the target LGAs to come forward and get vaccinated,"

Since May 2019, more than 55 suspected cases have been reported across 8 LGAs in Ebonyi State, most of which have been reported in recent weeks from Izzi LGA. Already, 9 of the suspected cases had samples that tested positive for yellow fever, and further tests are pending. The outbreak has resulted in a high number of deaths, as 20 of the suspect cases have died (case fatality ratio (CFR) 40%). The scope of the response is, therefore, in Izzi LGA and surrounding LGAs with contiguous borders (such as, Abakaliki in Ebonyi State, Yala LGA in Cross River state, and Ada and Oju LGAs in Benue State).

A rapid response team (RRT) under the leadership of the National Primary Health Care Development Agency (NPHCDA) and Nigeria Centre for Disease Control (NCDC), composed of Ebonyi State health authorities, WHO and other partners, was deployed to investigate the cases, strengthen efforts to control virus circulation and sensitize health workers and communities on prevention methods against yellow fever.

While vaccination is the best-known measure for keeping people protected for life, Dr Joseph Oteri, NPHCDA Director Disease Control and Immunization, implores people to protect themselves and their families. According to him, "Reducing exposure to mosquitoes, including the use of insect repellent to avoid bites both during the day and at night and removing potential breeding sites such as standing water containers are also effective."

The response of the outbreak in Ebonyi State is part of the global strategy to Eliminate Yellow Fever Epidemics (EYE) by 2026. With the support from WHO, UNICEF, Gavi, the Vaccine Alliance and more than 50 partners, Nigeria has developed a 10-year strategic elimination plan to improve yellow fever diagnosis capacity, childhood immunization and overall population immunity in all states.

Nigeria is a priority country for the EYE Strategy, and it is expected that more than 75 million people will be protected against yellow fever in the country by the end of 2021.

The impact of the EYE strategy is already tangible, with more than 35 million people vaccinated during outbreak response and preventive mass campaigns aimed at establishing high population immunity. Efforts will continue towards full implementation of the EYE 10-year plan to eliminate yellow fever outbreaks.

"Thanks to the leadership of the Nigeria Center for Disease Control, yellow fever surveillance has strengthened and improved, enabling quick outbreak detection and rapid response," said Thabani Maphosa, Gavi Country Programmes Managing Director. "However, the global vaccine stockpile is our last line of defense against the growing threat of yellow fever outbreaks. The most important long-term strategy is high coverage of yellow fever vaccination during preventive campaign and in routine immunisation so every child is protected, preventing outbreaks from happening in the 1st place."

For the record, from the onset of the outbreak in September 2017 to December 2018, 3902 suspected cases were reported from all 36 states and the FCT in Nigeria. Out of the 3295 samples collected and tested, 185 were presumptive positive in country and were sent for confirmation to the Institute Pasteur (IP) Dakar for further testing. From the results, 78 positive cases from 14 states (Kwara, Kogi, Kano, Zamfara, Kebbi, Nasarawa, Niger, Katsina, Edo, Ekiti, Rivers, Anambra, FCT, and Benue States) were confirmed at IP Dakar (Source: NCDC).

Furthermore, Gavi-supported YF preventive mass vaccination campaigns were conducted in 6 other states (Borno, Kebbi, Niger, Plateau, Sokoto and the FCT) between 22 Nov - 2 Dec 2018, bringing the total states covered by preventive mass vaccination campaigns in Nigeria to 12.

Yellow fever is an acute viral haemorrhagic disease transmitted by infected mosquitoes. The "yellow" in the name refers to the jaundice that affects some patients. Symptoms of yellow fever include fever, headache, jaundice, muscle pain, nausea, vomiting and fatigue. Vaccination is the most important means of preventing yellow fever. To prevent further spread, pre-emptive vaccination campaigns are required in neighboring areas not directly affected by the ongoing yellow fever outbreak and reactive campaigns but which face heightened risk and vulnerability.
=========================
[This report provides a broader overview of the recent yellow fever (YF) situation in Nigeria. Although the current cases occurred in Ebonyi state, local government areas in adjacent Benue and Cross River states are considered at risk and are prudently included in the vaccination campaign. The previous report indicated that as of Wed 31 Jul 2019, 78 cases have been laboratory confirmed in Nigeria in 2019 (see Yellow fever - Africa (11): Nigeria (EB) http://promedmail.org/post/20190814.6622764). There is still no confirmation of the cause of 8 illnesses and 6 deaths of schoolgirls who had visited a national park where there was one confirmed and one probable YF case (see Undiagnosed illness - Nigeria (02): (BO) fatal, poss. link to game reserve, RFI  http://promedmail.org/post/20190906.6660123).

Map of Nigeria:
<https://maps-nigeria.com/img/1200/map-of-nigeria-showing-the-geopolitical-zones.jpg>. - ProMED Mod.TY]

[HealthMap/ProMED map available at:
Nigeria: <http://healthmap.org/promed/p/62>]
Date: Thu 5 Sep 2019
From: Marycelin Baba [edited]

The number of deaths is still uncertain. It has been presumptively diagnosed as yellow fever. Knowing the mode of transmission of yellow fever and the low population immunity especially in Borno State, more transmission is ongoing. I think ELISA was used for the presumptive diagnosis. Plans are being made to ship the IgM positive samples to Dakar for confirmation. I have also requested that part of the samples should be sent to the Arbovirus Laboratory at University of Maiduguri Teaching Hospital (UMTH) for confirmation. At UMTH, plaque assay would be used for confirmation within 4 days.
---------------------------------------------
EpiCore Surveillance Project member
Professor Marycelin Baba
University of Maiduguri
Nigeria
**************************************
Bauchi: Yankari Game Reserve
Date: Fri 6 Sep 2019
Source: EpiCore Global Surveillance Project [edited]

[The following information was submitted by an EpiCore Surveillance Project member who wishes to remain anonymous.]

The Nigeria Centre for Disease Control [NCDC] has confirmed 4 cases of yellow fever in Bauchi State. 3 of the confirmed cases are residents of Alkaleri Local Government Area (LGA) and the 4th case is a tourist who was visiting Kano State and also visited the Yankari Games Reserve in the same LGA in Bauchi State.

NCDC was first notified on [29 Aug 2019], when it received the report of a confirmed case of yellow fever in Kano State from a laboratory in its yellow fever laboratory network. Subsequent investigations led by the Kano State Epidemiology Team established that this confirmed case of yellow fever was from a patient who visited the Yankari Game Reserve in Bauchi, in August 2019 with his father. Unfortunately, the father died with similar symptoms before a sample could be collected and tested.

Subsequently, on [3 Sep 2019], the Borno State Epidemiology Team reported deaths among students of Waka College of Education in Biu LGA Borno State. These students visited the Yankari Game Resort in August 2019. Of the 95 students who visited the resort, 8 developed symptoms and 6 had died as at the time of the report. The others are in a stable condition. Samples from these cases are being tested.

Intensification of surveillance activities has led to the identification of 3 more confirmed cases who are all resident in Alkaleri Local Government Area (LGA), of Bauchi state.

Altogether, 4 cases of yellow fever were confirmed in people that either live or have visited Bauchi in the last one month.

Since it was notified, the NCDC has collaborated with the State epidemiologists of the affected States and the World Health Organization country office to investigate these events. The agency has also deployed a rapid response team to support Bauchi State to carry out further in-depth investigations, including case finding, risk communications, and support the management of cases. Samples of the other suspected cases from Bauchi and Borno states are currently being transported to the NCDC National Reference Laboratory in Abuja for further testing.
******************************************
Osun: ACEGID offer of assistance
Date: Thu 6 Sep 2019
From: Philomena Eromon <Eromonp@run.edu.ng> [edited]

With the recent development in Biu [Local Government Area in southern Borno State], I am very much concerned as a citizen of Nigeria, who also has a connection with Biu. I am a research scientist with the African Center of Excellence for the Genomics of Infectious Disease [ACEGID]. We are located in Redeemers University Ede Osun State and we're concerned with outbreaks as this. My advice will be to send plasma samples of those who are sick and their possible contact for a whole genome sequencing which will unravel these mysterious illness. We have the platform and have used it in such capacity. Contact me at <Eromonp@run.edu.ng> should you want more information. You can also check our site <http://www.acegid.org>
-----------------------------------------------
Philomena Eromon
African Center of Excellence for Genomics of Infectious Diseases,
Redeemer's University
Ede
Nigeria
Eromonp@run.edu.ng
===========================
[ProMED thanks Philomena Eromon, Prof Baba, and anonymous EpiCore members who have submitted rapid responses to this request for further information. The possibility of toxic ingestion as well as yellow fever are discussed by other ProMED moderators as follows. - ProMED Mod.LXL]

[These cases, if limited to the Waka Biu College group, would be unusual for yellow fever on epidemiological grounds. However, the occurrence of a yellow fever case in the Yankari Game Reserve that the students also visited indicates that YF virus was circulating there and there were additional YF cases in the state. Nonetheless, the occurrence of a cluster of 16 simultaneous cases with just one report of other cases in the area where the students and photographers had been argues against yellow fever virus transmission. One would expect to see a chain of cases, not an abrupt outbreak with all coming down with illness at the same time. Sylvan spill-over of YF virus is also unlikely for the same reason. However the case fatality rate (4 dead of 16 cases) is about right for YF. It would be important to know if any of the ill individuals had been vaccinated against YF. Laboratory confirmation of the etiology of these 16 student cases is essential to know the cause of their illness. - ProMED Mod.TY]

[There are very few clinical signs to attempt to make a diagnosis. However, if the individuals did not purchase water or food, then one wonders whether the food they may have taken with them was spoiled in some way. These individuals swam in the water. A number of things come to mind, such as blue-green algae or cyanobacteria, that could be the cause. One also wonders whether the water had coliform or other bacteria or toxins which could have affected these individuals in the manner described. If others have additional information, we would appreciate knowing. Please send to <promed@promedmail.org>. - ProMED Mod.TG]

[Maps of Nigeria:
<https://maps-nigeria.com/img/1200/map-of-nigeria-showing-the-geopolitical-zones.jpg>
and <http://healthmap.org/promed/p/62>]
Date: Wed 4 Sep 2019
Source: Premium Times [edited]
<https://www.premiumtimesng.com/regional/nnorth-east/350476-four-dead-12-hospitalised-as-strange-illness-afflicts-college-students.html>

At least 4 people have been confirmed dead and 12 hospitalized after students of the College of Education, Waka-Biu in Biu Local Government Area of Borno State returned from a Yankari Games Reserve field trip. According to witnesses who spoke to Premium Times on [the] phone from Biu, those that lost their lives complained of abdominal pains after which they vomited blood. Initially, the death toll was put at 9, a figure which the Provost of the school, Mohammed Audu, said was incorrect.

Biu has been thrown into confusion in the last few days as the strange illness continues to affect mainly students of the institution. One of the dead students is the daughter of the caretaker chairman of Biu Local Government Area. The Borno State Deputy Governor, Umar Kadafur, who hails from Biu, has also confirmed the development.

Speaking through his Press Secretary, Bulama Alkali, the deputy governor, said the Borno State health ministry and the federal ministry of health have been directed to investigate the matter. "For now the deputy governor may not have ample information that will enable him [to] make [an] informed comment on the matter," said Mr. Alkali. "However the deputy governor, just like any other parent, is very much saddened and concerned about the development," he added.

The College Provost, Mr. Audu, said the students were on holiday at the time they embarked on the field trip to Yankari. He said the "school was closed for the season on 10 Aug 2019. But the students had to return to the campus to embark on the excursion because it was already planned, and they had to go for the trip as part of their course work."

He said the field trip was done in 3 batches, and the last batch that encountered the problem was "batch C" who travelled on 21 Aug 2019 and returned a day later. The excursion has been an annual event for students, he said. "When they returned, they left for their homes and there was no issue until Saturday, 31 Aug 2019, when the daughter of [the] Biu local government chairman died," he said. The provost said even when the female student died, her death was not immediately linked with the Yankari trip.

"People began to raise eyebrows some days after when 3 other students who were in the same trip batch died after exhibiting similar health conditions," he said. Mr. Audu said tension began to mount when more of the students fell ill. "Of the 4 that died, 2 were not our students but the commercial photographers that usually accompany the students on such trips," he said. One of the photographers was said to be asthmatic.

The provost explained that he wrote to the General Hospital in Biu alerting the Principal Medical Officer (PMO) of the situation in the college following the death of one of the students. He said he also alerted the state government, which deployed an emergency medical response team to Biu from Maiduguri. "Meanwhile, the PMO in Biu had mobilized his team to the school after all the students on the last batch that contracted the unknown disease were summoned back to the campus," Mr. Audu said.

Mr. Audu said the students were questioned on the kind of food they ate and the water they drank. "Most of them said they couldn't eat the food sold in Yankari because [it was] very expensive, but they all said they swam in the stream there. The PMO assured them that though the strange ailment has no signs of being communicable, it's root cause has to be verified in a laboratory test."

The provost informed Premium Times that some of the students that were examined exhibited symptoms of being ill. A total of 12 of them were not feeling very well, and the medics gave them some medication and asked them to return for further medical examination by the medical team from Maiduguri. "However, the PMO had to refer 3 of the ill with more severe case[s] of ailment to be admitted at the hospital," he said.

Efforts to contact the Borno State health commissioner and his counterpart in the ministry of higher education were not successful, as they could not be reached on their known mobile lines.

Premium Times gathered that the Waka Biu students' travail may not have been isolated. One of the medical personnel was quoted to have said that a similar case was reported in Kano after a set of students from the Northwest state visited Yankari reserve on the same day, 21 Aug 2019.

Although Premium Times has not independently verified that piece of information, the medical personnel feel strongly that the strange illness has a lot to do with the popular games reserve. The medical team from Maiduguri is expected to reexamine the students.  [Byline: Abdulkareem Haruna]
====================
[The etiology of these illnesses is unclear. With the bleeding, a viral hemorrhagic fever such as Lassa or yellow fever could be considered. ProMED would appreciate any information regarding this outbreak.

Yankari National Park (<https://en.wikipedia.org/wiki/Yankari_National_Park>) is a large wildlife park located in the south-central part of Bauchi State, in northeastern Nigeria. It covers an area of about 2244 square km (866 sq mi) and is home to several natural warm water springs, as well as a wide variety of flora and fauna. Its location in the heartland of the West African savanna makes it a unique way for tourists and holidaymakers to watch wildlife in its natural habitat. Yankari was originally created as a game reserve in 1956 but later designated Nigeria's biggest national park in 1991. It is the most popular destination for tourists in Nigeria and, as such, plays a crucial role in the development and promotion of tourism and ecotourism in Nigeria. It is also one of the most popular eco-destinations in West Africa. - ProMED Mod.LL

[HealthMap/ProMED-mail map:
Borno State, Nigeria: <http://healthmap.org/promed/p/621>]
More ...