Date: Thu 29 May 2019 Source: XinHuaNet [edited] <http://www.xinhuanet.com/english/2019-05/30/c_138100702.htm
Cholera has killed one and left 32 others hospitalized in Tanzania's commercial capital, Dar es Salaam, Tanzanian health minister Ummy Mwalimu said on Wed 28 May 2019. "The outbreak of the disease has been caused by failure to abide by hygienic regulations," the minister said.
She directed all municipal councils in the commercial capital to enact by-laws that impose stern punishment to people who empty cesspool tanks in the open when it rains. Instructions have been given to municipal council authorities to mete out stern punishment to anybody disposing sewage in their compounds, Mwalimu said.
Dar es Salaam chief medical officer Yudas Ndungile said most cholera patients came from Mchikichini, in Kariakoo, and places hardly reached by sewage vehicles, and that efforts should be put in place to reach those areas. ========================
[With the start of the rainy season in this area of East Africa, the number of cases of cholera will rise. The mortality from cholera and most diarrheal illnesses is related to non-replacement of fluid and electrolytes from the diarrheal illness.
As stated by Lutwick and colleagues (Lutwick LI, Preis J, Choi P. Cholera. In: Chronic illness and disability: the pediatric gastrointestinal tract. Greydanus DE, Atay O, Merrick J, editors. New York: Nova Bioscience; 2018:113-127), oral rehydration therapy can be life-saving in outbreaks of cholera and other forms of diarrhea:
"As reviewed by Richard Guerrant et al. (1), it was in 1831 that cholera treatment could be accomplished by intravenous replacement, and, although this therapy could produce dramatic improvements, not until 1960 was it 1st recognized that there was no true destruction of the intestinal mucosa, and gastrointestinal rehydration therapy could be effective, and the therapy could dramatically reduce the intravenous needs for rehydration. Indeed, that this rehydration could be just as effective given orally as through an orogastric tube (for example, refs 2 and 3) made it possible for oral rehydration therapy (ORT) to be used in rural remote areas and truly impact the morbidity and mortality of cholera. Indeed, Guerrant et al. (1) highlight the use of oral glucose-salt packets in war-torn Bangladeshi refugees, which reduced the mortality rate from 30% to 3.6% (4) and quotes sources referring to ORT as "potentially the most important medical advance" of the 20th century. A variety of formulations of ORT exist, generally glucose or rice powder-based, which contain a variety of micronutrients, especially zinc (5).
"The assessment of the degree of volume loss in those with diarrhoea to approximate volume and fluid losses can be found in ref 6 below. Those with severe hypovolemia should be initially rehydrated intravenously with a fluid bolus of normal saline or Ringer's lactate solution of 20-30 mL/kg followed by 100 mL/kg in the 1st 4 hours and 100 mL/kg over the next 18 hours with regular reassessment. Those with lesser degrees of hypovolemia can be rehydrated orally with a glucose or rice-derived formula with up to 4 L [4.2 qt] in the 1st 4 hours, and those with no hypovolemia can be given ORT after each liquid stool with frequent re-evaluation."